Dr. George Perry
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Dr. George Perry

Professor
University of Texas at San Antonio, America

Highest Degree
PostDoc Fellow in Cell Biology from Baylor College of Medicine, USA

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Biography

Dr. George Perry is Professor of Biology at The University of Texas at San Antonio. He has completed his PhD in Marine Biology from Scripps Institution of Oceanography. Dr. Perry is recognized in the field of Alzheimer disease research particularly for his work on Oxidative Stress. He is distinguished as one of the top Alzheimer Disease Researchers with over 1000 research articles published in journals, and one of the top 100 most-cited scientists in neuroscience and behavior and one of the top 25 scientists in free radical research. Dr. Perry has been cited over 100,000 times (H=157), recognized as an ISI highly cited researcher and Top Expert in Alzheimer Disease determined by Expertscape. Dr. Perry is Editor-in-Chief for the Journal of Alzheimer Disease. He is a fellow of the American Association for the Advancement of Sciences, Microscopy Society of America, International Engineering and Technology Institute, Texas Academy of Sciences, Association of Biotechnology and Pharmacy (FABAP), Royal Society of Medicine, Royal Society of Chemistry (FRSC, CChem), Linnean Society of London (FLS), Royal College of Pathologists (FRCPath), Royal Society of Biology (FRSB, CBiol, CSci), Royal Society for the encouragement of Arts, Manufactures and Commerce (FRSA), Royal Microscopical Society (FRMS) and past-president and interim-executive director of the Southwestern and Rocky Mountain Division of the American Association for the Advancement of Science and past-president of the American Association of Neuropathologists. He is Foreign Correspondent Member of the Spanish Royal Academy of Sciences, Foreign Corresponding Member of the Academy of Sciences Lisbon, and corresponding member of the Mexican Academy of Sciences, Member of the Iberoamerican Molecular Biology Organization, and member of the Dana Alliance for Brain Initiatives and Senior Fulbright Fellow. He was awarded the Panama National Plaque of Honor for Excellence in Neuroscience, Senior Investigator Award, International College of Geriatric Psychoneuropharmacology, Rous Whipple Award-American Society for Investigative Pathology, Distinguished Texas Scientist of the Texas Academy of Sciences, Denham Harmon Award of the American Aging Association and Martin Goland Award of the Alamo Chapter of Sigma Xi and many others. His research is primarily focused on how Alzheimer disease develops and the physiological consequences of the disease at a cellular level. He is currently working to determine the sequence of events leading to damage caused by and the source of increased Oxygen Radicals.

Area of Interest:

Biomedical Sciences
100%
Neuroscience
62%
Alzheimera`s Disease
90%
Amyloid Formation
75%
Oxidative Stress
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Rueli, R.H., D.J. Torres, A.S. Dewing, A.C. Kiyohara and S.M. Barayuga, 2017. Selenoprotein S reduces endoplasmic reticulum stress-induced phosphorylation of Tau: Potential role in selenate mitigation of Tau pathology. J. Alzheimer's Dis., 55: 749-762.
    CrossRef  |  PubMed  |  Direct Link  |  
  2. Yu, L., R.A. Rodriguez, L.L. Chen, L.Y. Chen, G. Perry, S.F. McHardy and C.K. Yeh, 2016. 1,3-propanediol binds deep inside the channel to inhibit water permeation through aquaporins. Protein Sci., 25: 433-441.
    CrossRef  |  PubMed  |  Direct Link  |  
  3. Wang, C., F. Zhang, S. Jiang, S.L. Siedlak and L. Shen, 2016. Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease. Sci. Rep., Vol. 6. 10.1038/srep20352.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. Sharoar, M.G., Q. Shi, Y. Ge, W. He and X. Hu, 2016. Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease. Mol. Psychiatry, 21: 1263-1271.
    CrossRef  |  PubMed  |  Direct Link  |  
  5. Plascencia-Villa, G., A. Ponce, J.F. Collingwood, M.J. Arellano-Jimenez and X. Zhu et al., 2016. High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer's disease. Sci. Rep., Vol. 6. 10.1038/srep24873.
    CrossRef  |  PubMed  |  Direct Link  |  
  6. Pistollato, F., E.L. Ohayon, A. Lam, G.R. Langley and T.J. Novak et al., 2016. Alzheimer disease research in the 21st century: Past and current failures, new perspectives and funding priorities. Oncotarget, 7: 38999-39016.
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  7. Ontiveros-Torres, M.A., M.L. Labra-Barrios, S. Diaz-Cintra, A.R. Aguilar-Vazquez and S. Moreno-Campuzano et al., 2016. Fibrillar amyloid-β accumulation triggers an inflammatory mechanism leading to hyperphosphorylation of the carboxyl-terminal end of tau polypeptide in the hippocampal formation of the 3×Tg-AD transgenic mouse. J. Alzheimers Dis., 52: 243-269.
    CrossRef  |  PubMed  |  Direct Link  |  
  8. Nunomura, A., T. Tamaoki, N. Motohashi, H.G. Lee, X. Zhu and G. Perry, 2016. Oxidative Stress and Neuropsychiatric Disorders in the Life Spectrum. In: Reactive Oxygen Species in Biology and Human Health, Ahmad. S.I. (Ed.). CRC Press, Boca Raton, FL., USA., ISBN-13: 9781498735469, pp: 157-163.
  9. Martin-Maestro, P., R. Gargini, G. Perry, J. Avila and V. Garcia-Escudero, 2016. PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease. Hum. Mol. Genet., 25: 792-806.
    CrossRef  |  PubMed  |  Direct Link  |  
  10. Manassero, G., M. Guglielmotto, R. Zamfir, R. Borghi and L. Colombo et al., 2016. Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein. Aging Cell., 15: 914-923.
    CrossRef  |  PubMed  |  Direct Link  |  
  11. Kelley, A.R., G. Perry, R.J. Castellani and S.B. Bach, 2016. Laser-induced in-source decay applied to the determination of amyloid-beta in Alzheimer's brains. ACS Chem. Neurosci., 7: 261-268.
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  12. Kelley, A.R., G. Perry, C. Bethea, R.J. Castellani and S.B. Bach, 2016. Molecular mapping Alzheimer's disease: MALDI imaging of formalin-fixed, paraffin-embedded human hippocampal tissue. Open Neurol. J., 10: 88-98.
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  13. Itzhaki, R., R. Lathe, B.J. Balin, M.J. Ball and E.L. Bearer et al., 2016. Microbes and Alzheimer's disease. J. Alzheimer's Dis., 51: 979-984.
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  14. Hofer, T. and G. Perry, 2016. Nucleic acid oxidative damage in Alzheimer's disease-explained by the hepcidin-ferroportin neuronal iron overload hypothesis? J. Trace Elem. Med. Biol., 38: 1-9.
    CrossRef  |  Direct Link  |  
  15. Herrera, L., D.E. Stephens, A. D'Avila, K.G. George and H. Arman et al., 2016. Insights into the structural patterns of the antileishmanial activity of bi- and tricyclic N-heterocycles. Org. Biomol. Chem., 14: 7053-7060.
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  16. Forero, D.A., Y. Gonzalez-Giraldo, C. Lopez-Quintero, L.J. Castro-Vega, G.E. Barreto and G. Perry, 2016. Telomere length in Parkinson's disease: A meta-analysis. Exp. Gerontol., 75: 53-55.
    CrossRef  |  PubMed  |  Direct Link  |  
  17. Forero, D.A., Y. Gonzalez-Giraldo, C. Lopez-Quintero, L.J. Castro-Vega, G.E. Barreto and G. Perry, 2016. Meta-analysis of telomere length in Alzheimer's disease. J. Gerontol. A Biol. Sci. Med. Sci., 71: 1069-1073.
    CrossRef  |  PubMed  |  Direct Link  |  
  18. Forero, D.A., C.F. Prada and G. Perry, 2016. Functional and genomic features of human genes mutated in neuropsychiatric disorders. Open Neurol. J., 10: 143-148.
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  19. Forero, D.A., A. Wonkam, W. Wang, P. Laissue and C. Lopez-Correa et al., 2016. Current needs for human and medical genomics research infrastructure in low and middle income countries. J. Med. Genet., 53: 438-440.
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  20. Correia, S.C., G. Perry and P.I. Moreira, 2016. Mitochondrial traffic jams in Alzheimer's disease-pinpointing the roadblocks. Biochimica Biophysica Acta (BBA)-Mol. Basis Dis., 1862: 1909-1917.
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  21. Castellani, R.J., S.C. Correia, P.I. Moreira and G. Perry, 2016. Tackling Alzheimer's Disease by Targeting Oxidative Stress and Mitochondria. In: Developing Therapeutics for Alzheimer's Disease: Progress and Challenges, Wolfe, M. (Ed.). Chapter 18, Elsevier Publishing, Amsterdam, The Netherlands, ISBN-13: 9780128021644, pp: 477-502.
  22. Castellani, R.J., G. Mojica and G. Perry, 2016. The role of the iron stain in assessing intracranial hemorrhage. Open Neurol. J., 10: 136-142.
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  23. Carvalho, C., S.C. Correia, G. Perry, R.J. Castellani and P.I. Moreira, 2016. Cerebrovascular and mitochondrial abnormalities in Alzheimer's disease: A brief overview. J. Neural Transmission, 123: 107-111.
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  24. Calderon-Garciduenas, L., R. Reynoso-Robles, J. Vargas-Martinez, A. Gomez-Maqueo-Chew and B. Perez-Guille et al., 2016. Prefrontal white matter pathology in air pollution exposed Mexico City young urbanites and their potential impact on neurovascular unit dysfunction and the development of Alzheimer's disease. Environ. Res., 146: 404-417.
    CrossRef  |  PubMed  |  Direct Link  |  
  25. Aryan, N., B.S. Betts-Obregon, G. Perry and A.T. Tsin, 2016. Oxidative stress induces senescence in cultured RPE cells. Open Neurol. J., 10: 83-87.
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  26. Zhang, F., W. Wang, S.L. Siedlak, Y. Liu and J. Liu et al., 2015. Miro1 deficiency in amyotrophic lateral sclerosis. Front. Aging Neurosci., Vol. 7. 10.3389/fnagi.2015.00100.
    CrossRef  |  PubMed  |  Direct Link  |  
  27. Zhang, F., B. Su, C. Wang, S.L. Siedlak and S. Mondragon-Rodriguez et al., 2015. Posttranslational modifications of α-tubulin in alzheimer disease. Transl. Neurodegener., Vol. 4. 10.1186/s40035-015-0030-4.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Spremo-Potparevic, B., V. Bajic, G. Perry and L. Zivkovic, 2015. Alterations of the X chromosome in lymphocytes of Alzheimer's disease patients. Curr. Alzheimer Res., 12: 990-996.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. Smith, G., G. Perry and J.W. Ashford, 2015. Advances in Alzheimer's Disease 4: Handbook of Depression in Alzheimer's Disease. IOS Press, Amsterdam, Netherlands., Pages: 381.
  30. Rodriguez, A.R., G. Plascencia-Villa, C.M. Witt, J.J. Yu and M. Jose-Yacaman et al., 2015. Chlamydia pneumoniae promotes dysfunction of pancreatic beta cells. Cell. Immunol., 295: 83-91.
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  31. Rodrigues, R., G. Perry and R. Petersen, 2015. Basis and argument into the work parallels on depression and alzheimer's disease and different genomic vulnerability leading to therapeutic utilities. Int. J. Neurol. Neurother., Vol. 2. .
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  32. Rodrigues, R., F. Ahmad, G. Perry and R. Petersen, 2015. Synergy between depression and Alzheimer's disease: A spectrum model of genomic vulnerability with therapeutic implications. Integrative Mol. Med., 2: 139-141.
  33. Rahman, A.U., M.I. Choudhary and G. Perry, 2015. Overview. Min. Rev. Med. Chem., 15: 2-3.
  34. Petersen, R.B., F.M. Lissemore, B. Appleby, N. Aggarwal and R. Boyatzis et al., 2015. From neurodegeneration to brain health: An integrated approach. J. Alzheimers Dis., 46: 271-283.
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  35. Perry, G., 2015. Meet the editorial board. Curr. Protein Peptide Sci., 16: 181-181.
  36. Perry, G., 2015. Meet our editorial board member. Min. Rev. Med. Chem., 15: 719-719.
  37. Perry, E.A. and G. Perry, 2015. Cellular pathology of Alzheimer disease. Cell Dev. Biol., Vol. 4. 10.4172/2168-9296.1000e134.
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  38. Pelcovits, A., R. Marriotti, J. Heath, G. Perry and R.J. Castellani, 2015. Simultaneous onset of Alzheimer's disease in a husband and wife in their mid-fifties: What do we really know about environmental factors? Open Neurol. J., 9: 1-3.
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  39. Mohorovic, L., A.M. Lavezza, S. Stifter, G. Perry, D. Malatestinic, V. Micovic and E. Materljan, 2015. Ferric iron brain deposition as the cause, source and originator of chronic neurodegenerative diseases. Environ. Anal. Chem., Vol. 2. 10.4172/2380-2391.1000169.
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  40. Luna-Munoz, J., G. Perry and J. Guevara, 2015. Raul Mena: 1953-2014. J. Alzheimer Dis., 45: 325-327.
    PubMed  |  Direct Link  |  
  41. Jiang, Z., W. Wang, G. Perry, X. Zhu and X. Wang, 2015. Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis. Transl. Neurodegener., 10.1186/s40035-015-0037-x.
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  42. Hammack, C.D., G. Perry, R.G. LeBaron, G. Villareal and C.F. Phelix, 2015. Low dose pioglitazone attenuates oxidative damage in early Alzheimer's disease by binding mitoNEET: Transcriptome-to-reactome™ biosimulation of neurons. Int. J. Knowledge Discov. Bioinform., 5: 24-45.
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  43. Gerenu, G., K. Liu, J.E. Chojnacki, J.M. Saathoff and Martinez-Martin et al., 2015. A curcumin/melatonin hybrid, 5-(4-hydroxy-phenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide, ameliorates AD-like pathology in the APP/PS1 mouse model. ACS Chem. Neurosci., 6: 1393-1399.
    CrossRef  |  PubMed  |  Direct Link  |  
  44. Correia, S.C., P.I. Moreira and G. Perry, 2015. Autophagy in Alzheimer's Disease: A Cleaning Service Out-of-Order? In: Current Topics in Neurotoxicity 9: Toxicity and Autophagy in Neurodegenerative Disorders, Fuentes, J.M. (Ed.). Springer International Publishing, Switzerland, pp: 123-142.
  45. Castellani, R.J., G. Perry and G.L. Iverson, 2015. Chronic effects of mild neurotrauma: putting the cart before the horse? J. Neuropathol. Exp. Neurol., 74: 493-499.
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  46. Calderon-Garciduenas, L., M. Franco-Lira, A. D`Angiulli, J. Rodriguez-Diaz and E. Blaurock-Busch et al., 2015. Mexico city normal weight children exposed to high concentrations of ambient PM 2.5 show high blood leptin and endothelin-1, vitamin D deficiency and food reward hormone dysregulation versus low pollution controls: Relevance for obesity and Alzheimer disease. Environ. Res., 140: 579-592.
    CrossRef  |  PubMed  |  Direct Link  |  
  47. Calderon-Garciduenas, L., C.K. Chao, C. Thompson, J. Rodriguez-Diaz, M. Franco-Lira, P.S. Mukherjee and G. Perry, 2015. CSF biomarkers: Low amyloid-I21-42 and BDNF and High IFN I3 differentiate children exposed to Mexico city high air pollution V controls. Alzheimera's disease uncertainties. J. Alzheimers Dis. Parkinsonism, Vol. 5. 10.4172/2161-0460.1000189.
    CrossRef  |  Direct Link  |  
  48. Calderon-Garciduenas, L., A. Gonzalez-Maciel, A. Vojdani, M. Franco-Lira and R. Reynoso-Robles, 2015. The intestinal barrier in air pollution-associated neural involvement in Mexico city residents: Mind the gut, the evolution of a changing paradigm relevant to parkinson disease risk. J. Alzheimers Dis. Parkinsonism, Vol. 5. 10.4172/2161-0460.1000179.
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  49. Bowen, R.L., G. Perry, C. Xiong, M.A. Smith and C.S. Atwood, 2015. A clinical study of lupron depot in the treatment of women with Alzheimer's disease: Preservation of cognitive function in patients taking an acetylcholinesterase inhibitor and treated with high dose lupron over 48 weeks. J. Alzheimer's Dis., 44: 549-560.
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  50. Bajic, V., B. Stanojevic, L. Zivkovic, A. Cabarkapa, G. Perry, T. Arendt and B. Spremo-Potparevic, 2015. Cyclin dependent kinase 11, neuroinflammation and Alzheimer's disease: A review. J. Clin. Cell. Immunol., Vol. 6. 10.4172/2155-9899.1000305.
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  51. Avila, J., G. Perry, B.A. Strange and F. Hernandez, 2015. Alternative neural circuitry that might be impaired in the development of Alzheimer disease. Front Neurosci., 10.3389/fnins.2015.00145.
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  52. Xia, J., D.M. Rocke, G. Perry and M. Ray, 2014. Differential network analyses of alzheimer's disease identify early events in alzheimer's disease pathology. Int. J. Alzheimer's Dis., Vol. 2014. 10.1155/2014/721453.
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  53. Wang, X., W. Wang, L. Li, G. Perry, H.G. Lee and X. Zhu, 2014. Oxidative stress and mitochondrial dysfunction in Alzheimer's disease. Biochim. Biophys. Acta., 1842: 1240-1247.
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  54. Ruegner, C.N., M. Benton, N. Dunsmore, G. Perry and R.J. Castellani, 2014. Colonic adenocarcinoma of a neovagina in a patient with mullerian agenesis. Reprod. Syst. Sexual Disorders, Vol. 3. 10.4172/2161-038X.1000138.
    CrossRef  |  Direct Link  |  
  55. Rosen, A.C., J.W. Ashford and G. Perry, 2014. Ethics review as a catalyst for progress. J. Alzheimers Dis., 40: 233-235.
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  56. Rodrigues, R., R.B. Petersen and G. Perry, 2014. Parallels between major depressive disorder and Alzheimer's disease: Role of oxidative stress and genetic vulnerability. Cell Mol. Neurobiol., 34: 925-949.
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  57. Perry, G., 2014. In praise of pathologists: A commencement address delivered at the university of Maryland in Baltimore, pathologists' As-Sistants graduate program. Atlas J. Med. Biol. Sci., 1: 23-25.
  58. Perry, G., 2014. Looking at Alzheimer's disease from a different angle. Future Neurol., 9: 19-22.
  59. Perry, E.A., R.J. Castellani and G. Perry, 2014. An epidemiological approach to the study of Alzheimer's disease. Int. J. Clin. Ther. Diagnosis, Vol. 2. .
    Direct Link  |  
  60. Perry, E.A., R.J. Castellani and G. Perry, 2014. A new outlook for Alzheimer's disease Atlas J. Med. Bio. Sci., 1: 21-22.
  61. Mondragon-Rodriguez, S., G. Perry, J. Luna-Munoz, M.C. Acevedo-Aquino and S. Williams, 2014. Phosphorylation of tau protein at sites Ser396-404 is one of the earliest events in Alzheimer's disease and Down syndrome. Neuropathol. Appl. Neurobiol., 40: 121-135.
    CrossRef  |  PubMed  |  Direct Link  |  
  62. Mohorovic, L., A.M. Lavezzi, S. Stifter, G. Perry and D. Malatestinic et al., 2014. Methemoglobinemia: A biomarker and a link to ferric iron accumulation in Alzheimer's disease. Adv. Biosci. Biotechnol., 5: 12-18.
    CrossRef  |  Direct Link  |  
  63. Johnston, J.M., W.T. Hu, D.W. Fardo, S.J. Greco and G. Perry et al., 2014. Low plasma leptin in cognitively impaired ADNI subjects: Gender differences and diagnostic and therapeutic potential. Current Alzheimer Res., 11: 165-174.
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  64. Johnston, J.M., G. Perry, J.W. Ashford and N. Tezapsidis, 2014. Leptin in Alzheimer's disease and other Cognitive Disorders and Association with Underlying Lipid Abnormalities. In: Leptin: Biosynthesis, Functions, and Clinical Significance, Blum, E.L. (Ed.)., Nova Science Publishers, Inc., Hauppauge, New York, pp: 1-16..
  65. Habibi, L., G. Perry and M. Mahmoudi, 2014. Global warming and neurodegenerative disorders: speculations on their linkage. Bioimpacts, 4: 167-170.
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  66. Fornicola, W., A. Pelcovits, B.X. Li, J. Heath, G. Perry and R.J. Castellani, 2014. Alzheimer disease pathology in middle age reveals a spatial-temporal disconnect between amyloid-β and phosphorylated tau. Open Neurol. J., 8: 22-26.
    CrossRef  |  PubMed  |  Direct Link  |  
  67. Forero, D.A., A. Velez-van-Meerbeke, S.N. Deshpande, H. Nicolini and G. Perry, 2014. Neuropsychiatric genetics in developing countries: Current challenges. World J. Psychiatry, 4: 69-71.
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  68. Fawver, J.N., Y. Ghiwot, C. Koola, W. Carrera and J. Rodriguez-Rivera et al., 2014. Islet Amyloid Polypeptide (IAPP): A second amyloid in Alzheimer's disease. Current Alzheimer Res., 11: 928-940.
    PubMed  |  Direct Link  |  
  69. Choudhary, M.I., G. Perry, A. Bosia, A. Nowe and A. Hostalkova et al., 2014. Recent Advances in Medicinal Chemistry. Bentham Science Publisher, Sharjah, United Arab Emirates, ISBN: 978-1-60805-797-9, Pages: 469.
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  70. Castellanim, R.J., A. Peclovits and G. Perry, 2014. Neuropathology of Alzheimer's Disease. In: Pathobiology of Human Disease, McManus, L.M. and R.N. Mitchell (Eds.). Elsevier, Oxford, UK., pp: 2014-2020.
  71. Castellani, R.J., A. Peclovits and G. Perry, 2014. Neuropathology of Alzheimer's Disease. In: Pathobiology of Human Disease, McManus, L.M. and R.N. Mitchell (Eds.). Elsevier, Oxford, UK., pp: 2014-2020.
  72. Castellani, R.J. and G. Perry, 2014. The complexities of the pathology-pathogenesis relationship in Alzheimer disease. Biochem. Pharmacol., 88: 671-676.
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  73. Castellani, R.J. and G. Perry, 2014. Pathogenesis of Alzheimer's disease. In: Handbook of Neurotoxicity, Kostrzewa, R.M.(Ed.)., Springer Science+Business Media, New York, pp: 2327-2337.
  74. Castellani, R. and G. Perry, 2014. Preface: Plaques and tangles: Birthmarks of the aging soul. Biochem. Pharmacol., 88: 423-425.
  75. Bonda, D.J., X. Wang, H.G. Lee, M.A. Smith, G. Perry and X. Zhu, 2014. Neuronal failure in Alzheimer's disease: A view through the oxidative stress looking-glass. Neurosci. Bull, 30: 243-252.
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  76. Bonda, D.J., J.G. Stone, S.L. Torres, S.L. Siedlak and G. Perry et al., 2014. Dysregulation of leptin signaling in Alzheimer disease: Evidence for neuronal leptin resistance. J. Neurochem., 128: 162-172.
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  77. Blair, J.A., S.L. Siedlak, J.A. Wolfram, A. Nunomura and R.J. Castellani et al., 2014. Accumulation of intraneuronal amyloid-β is common in normal brain. Current Alzheimer Res., 11: 317-324.
    PubMed  |  Direct Link  |  
  78. Zivkovic, L., B. Spremo-Potparevic, S.L. Siedlak, G. Perry, B. Plecas-Solarovic, Z. Milicevic and V.P. Bajic, 2013. DNA damage in Alzheimer disease lymphocytes and its relation to premature centromere division. Neurodegener. Dis., 12: 156-163.
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  79. Zhu, X., G. Perry, M.A. Smith and X. Wang, 2013. Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J. Alzheimers Dis., 33: S253-S256.
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  80. Williams, W.M., S. Torres, S.L. Siedlak, R.J. Castellani, G. Perry, M.A. Smith and X. Zhu, 2013. Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer's brain. J. Neuroinflammation, Vol. 10. 10.1186/1742-2094-10-127.
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  81. Schrag, M., C. Mueller, M. Zabel, A. Crofton and W.M. Kirsch et al., 2013. Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: A meta-analysis. Neurobiol. Dis., 59: 100-110.
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  82. Santos, R.X., S.C. Correia, X. Zhu, MA Smith and P.I. Moreira et al., 2013. Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease. Antioxid Redox. Signal., 18: 2444-2457.
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  83. Perry, G., X. Zhu, M.A. Smith, A. Sorensen and J. Avila, 2013. Preface: Alzheimer's disease: advances for a new century. J. Alzheimers Dis., Vol. 33. .
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  84. Perry, G., 2013. Foreword: The largest unmet market: Chronic diseases of aging. Mini. Rev. Med. Chem., Vol.13. .
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  85. Perry, E.A., R.J. Castellani, P.I. Moreira, A. Nunomura and Q. Lui et al., 2013. Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links. Free Radical Res., 47: 507-510.
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  86. Paley, E.L., G. Perry and O. Sokolova, 2013. Tryptamine induces axonopathy and mitochondriopathy mimicking neurodegenerative diseases via tryptophanyl-tRNA deficiency. Current Alzheimer Res., 10: 987-1004.
    PubMed  |  Direct Link  |  
  87. Mondragon-Rodriguez, S., G. Perry, X. Zhu, P.I. Moreira, M.C. Acevedo-Aquino and S. Williams, 2013. Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: implications for Alzheimer's disease. Oxid. Med. Cell. Longev., Vol.2013. 10.1155/2013/940603.
    CrossRef  |  Direct Link  |  
  88. Jarero-Basulto, J.J., J. Luna-Munoz, R. Mena, Z. Kristofikova and D. Ripova et al., 2013. Proteolytic cleavage of polymeric tau protein by caspase-3: Implications for Alzheimer disease. J. Neuropathol. Exp. Neurol., 72: 1145-1161.
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  89. Hou, L., H. Lee, F. Han, J.M. Tedesco, G. Perry, M.A. Smith and M.G. Zagorski, 2013. Modification of amyloid-β1-42 fibril structure by methionine-35 oxidation. J. Alzheimer's Dis., 37: 9-18.
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  90. Haldar, S., A.J. Beveridge, J. Wong, A. Singh and D. Galimberti et al., 2013. A low-molecular-weight ferroxidase is increased in the CSF of sCJD cases: CSF ferroxidase and transferrin as diagnostic biomarkers for sCJD. Antioxid. Redox Signaling, 19: 1662-1675.
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  91. Greco, S.J., G. Perry, J.W. Ashford, A. Hamzelou, J.M. Johnston and N. Tezapsidis, 2013. Leptin rescues neurons from Alzheimer's disease-related pathways triggered by lipid burden. Adv. Alzheimer's Dis., 2: 31-39.
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  92. Garcia-Escudero, V., P. Martin-Maestro, G. Perry and J. Avila, 2013. Deconstructing mitochondrial dysfunction in alzheimer disease. Oxid. Med. Cell. Longev, Vol. 2013. 10.1155/2013/162152.
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  93. Fujioka, H., C.F. Phelix, R.P. Friedland, X. Zhu, E.A. Perry, R.J. Castellani and G. Perry, 2013. Apolipoprotein E4 prevents growth of malaria at the intraerythrocyte stage: Implications for diff erences in racial susceptibility to Alzheimer's disease. J. Health Care Poor Underserved, 24: 70-78.
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  94. Duran-Gonzalez, J., E.D. Michi, B. Elorza, M.G. Perez-Cordova and L.F. Pacheco-Otalora et al., 2013. Amyloid β peptides modify the expression of antioxidant repair enzymes and a potassium channel in the septohippocampal system. Neurobiol. Aging, 34: 2071-2076.
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  95. Correia, S.C., R.X. Santos, M.S. Santos, G. Casadesus and J.C. LaManna et al., 2013. Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease. Current Alzheimer Res., 10: 406-419.
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  96. Correia, S.C., G. Perry, R. Castellani and P.I. Moreira, 2013. Is exercise-in-a-bottle likely to proffer new insights into Alzheimer's disease? J. Neurochem., 127: 4-6.
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  97. Colom, L.V., G. Perry and R.O. Kuljis, 2013. Tackling the elusive challenges relevant to conquering the 100-plus year old problem of Alzheimer' disease. Curr. Alzheimer Res., 10: 108-116.
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  98. Castellani, R.J., B.X. Li, A. Farshori and G. Perry 2013. Oxidative Stress and Alzheimer's Disease. In: Studies on Alzheimer Disease, Pratico, D. and P. Mecocci (Eds.). Springer Science, Business Media, New York, pp: 9-13.
  99. Bharadwaj, P.R., K.A. Bates, T. Porter, E. Teimouri and G.Perry et al., 2013. Latrepirdine: Molecular mechanisms underlying potential therapeutic roles in Alzheimer's and other neurodegenerative diseases. Transl. Psychiatry, 10.1038/tp.2013.97.
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  100. Alonso, A.D., C.X. Gong, G. Perry and J. Avila, 2013. Inge grundke-iqbal: A legacy of tau in the etiology of alzheimer disease (1937-2012). J. Alzheimer's Dis., 33: 1-2.
  101. Zhu, X., R.J. Castellani, P.I. Moreira, G. Aliev and J.C. Shenk et al., 2012. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover. Free Radical Biol. Med., 52: 699-704.
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  102. Zhu, X., R.J. Castellani, N.P. Ziats, R.B. Petersen, H.G. Lee and G. Perry, 2012. Obituary: Mark A. Smith: neurocytochemistry innovator. J. Neurochem., 120: 1139-1140.
  103. Zhu, X., H.G. Lee and G. Perry, 2012. Mark Anthony Smith (August 15, 1965-December 19, 2010): An Inspiration for Alzheimer's Disease. In: Neurodegenerative Diseases, Ahmad, S. (Ed.). Springer, Philadelphia, ISBN: 9781461406532, pp: xxxi-xxxii.
  104. Wise-Scira, O., L. Xu, G. Perry and O. Coskuner, 2012. Structures and free energy landscapes of aqueous zinc (II)-bound amyloid-β (1-40) and zinc (II)-bound amyloid-β (1-42) with dynamics. J. Biol. Inorg. Chem., 17: 927-938.
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  105. Williams, W.M., R.J. Castellani, A. Weinberg, G. Perry and M.A. Smith, 2012. Do β-defensins and other antimicrobial peptides play a role in neuroimmune function and neurodegeneration? Scient. World J., Vol. 2012. 10.1100/2012/905785.
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  106. Wang, X., M.H. Yan, H. Fujioka, J. Liu and A. Wilson-Delfosse et al., 2012. LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1. Human Mol. Genet., 21: 1931-1944.
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  107. Sheng, B., X. Wang, B. Su, H.G. Lee, G. Casadesus, G. Perry and X. Zhu, 2012. Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease. J. Neurochem., 120: 419-429.
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  108. Santos, R.X., S.C. Correia, X. Zhu, H.G. Lee and R.B. Petersen et al., 2012. Nuclear and mitochondrial DNA oxidation in Alzheimer's disease. Free Radical Res., 46: 565-576.
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  109. Rodrigues, R., M.A. Smith, X. Wang, G. Perry, H.G. Lee, X. Zhu and R.B. Petersen, 2012. Molecular neuropathogenesis of Alzheimer's disease: An interaction model stressing the central role of oxidative stress. Future Neurol., 7: 287-305.
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  110. Reed-Cossairt, A., X. Zhu, H.G. Lee, C. Reed, G. Perry and R.B. Petersen, 2012. Alzheimer's disease and vascular deficiency: Lessons from imaging studies and down syndrome. Curr. Gerontol. Geriatr. Res., Vol. 2012. 10.1155/2012/929734.
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  111. Piccini, A., R. Borghi, M. Guglielmotto, E. Tamagno and G. Cirmena et al., 2012. β-amyloid 1-42 induces physiological transcriptional regulation of BACE1. J. Neurochem., 122: 1023-1031.
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  112. Perry, G., X. Zhu, H.G. Lee R.B. Petersen and R.J. Castellani, 2012. Mark anthony Smith: Enthusiasm for tackling the intractable. Coord. Chem. Rev., 256: 2127-2128.
  113. Perry, G., M.I. Choudhary, M.L.L. Rodriguez, H. Kalasz and M. Bernard et al., 2012. Special issue in honor of the 70th birthday of Dr. Atta-ur-Rahman, FRS. Mini Rev. Med. Chem., Vol. 12. 10.2174/138955712802762347.
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  114. Perry, G., M.H. Yan, H. Fujioka, A. Wilson-Delfosse and S.G. Chen et al., 2012. LRRK2 directly interacts with DLP1 to regulate mitochondrial dynamics and function. Microsc. Microanal., 18: 196-197.
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  115. Perry, G., E.A. Perry, X. Zhu and R. Castellani, 2012. A pleotrophic age for Alzheimer and Parkinson disease. J. Alzheimers Dis. Parkinsonism, Vol. 2. 10.4172/2161-0460.1000e109.
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  116. Perry, G., C.F. Phelix, A. Nunomura, L.V. Colom and R.J. Castellani et al., 2012. Untangling the vascular web from Alzheimer disease and oxidative stress. Can. J. Neurol. Sci., 39: 4-4.
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  117. Perry, G., 2012. Journal of Huntington's disease-the family gets bigger. J. Alzheimer's Dis., 30: 735-735.
  118. Nunomura, A., T. Tamaoki, N. Motohashi, M. Nakamura and D.W. McKeel Jr. et al., 2012. The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons. J. Neuropathol. Exp. Neurol., 71: 233-241.
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  119. Nunomura, A., P.I. Moreira, R.J. Castellani, H.G. Lee, X. Zhu, M.A. Smith and G. Perry, 2012. Oxidative damage to RNA in aging and neurodegenerative disorders. Neurotox. Res., 22: 231-248.
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  120. Morelli, L., G. Perry and F. Tagliavini, 2012. The contribution of the amyloid hypothesis to the understanding of Alzheimer's disease: A critical overview. Int. J. Alzheimer's Dis., Vol. 2012. 10.1155/2012/709613.
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  121. Mondragon-Rodriguez, S., G. Perry, X. Zhu, P.I. Moreira and S. Williams, 2012. Glycogen synthase kinase 3: A point of integration in Alzheimer's disease and a therapeutic target? Int. J. Alzheimer's Dis., Vol. 2012. 10.1155/2012/276803.
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  122. Mondragon-Rodriguez, S., G. Perry, X. Zhu and J. Boehm, 2012. Amyloid beta and tau proteins as therapeutic targets for Alzheimer's disease treatment: Rethinking the current strategy. Int. J. Alzheimer's Dis., Vol. 2012. 10.1155/2012/630182.
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  123. Liu, G., P. Men, X. Zhu and G. Perry, 2012. Iron chelation and nanoparticle target delivery in the development of new multifunctional disease-modifying drugs for Alzheimer's disease. Ther. Deliv., 3: 571-574.
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  124. Liu, G., P. Men, G. Perry and M.A. Smith, 2012. Nanoparticle-Iron Chelator Conjugates as Multifunctional Disease-Modifying Drugs for Prevention and Treatment of Alzheimer's Disease. In: Nanomedicine and the Nervous System, Martin, C.R., V.R. Preedy and R.J. Hunter (Eds.). CRC Press, Boca Raton, Florida, pp: 347-366.
  125. Lee, H.G., G. Perry and X. Zhu, 2012. Mark Smith: Pioneer of Alzheimer disease research. Neurotoxic. Res., 22: 181-181.
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  126. Kudo, W., H.P. Lee, W.Q. Zou, X. Wang and G. Perry et al., 2012. Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death. Human Mol. Genet., 21: 1138-1144.
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  127. Klionsky, D.J., F.C. Abdalla, H. Abeliovich, R.T. Abraham and A. Acevedo-Arozena et al., 2012. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8: 445-544.
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  128. Joseph, J.A., G. Casadesus, M.A. Smith, G. Perry and B. Shukitt-Hale, 2012. Food Constituents in Cognitive Decline and Neurodegenerative Disease. In: Nutrition in the Prevention and Treatment of Disease. Coulston, A.M., C.J. Boushey and M. Ferruzzi (Eds.)., Elsevier Inc., San Diego, California, pp: 373-390.
  129. Guglielmotto, M., M. Aragno, E. Tamagno, I. Vercellinatto and S. Visentin et al., 2012. AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation. Neurobiol. Aging, 33: 196.e13-196.e27.
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  130. Greco, S.J., A. Hamzelou, J.M. Johnston, S. Richardson and M.A. Smith et al., 2012. Isotyping the human TOMM40 variable-length polymorphism by gene amplification and restriction digest. Current Alzheimer Res., 9: 1168-1173.
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  131. Coskuner, O., O. Wise-Scira, G. Perry and T. Kitahara, 2012. The structures of the E22Δ mutant-type amyloid-β alloforms and the impact of E22Δ mutation on the structures of the wild-type amyloid-β alloforms. ACS Chem. Neurosci., 4: 310-320.
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  132. Correia, S.C., R.X. Santos, G. Perry, X. Zhu, P.I. Moreira and M.A. Smith, 2012. Mitochondrial Importance in Alzheimer's, Huntington's and Parkinson's Diseases. In: Neurodegenerative Diseases, Ahmad, S.I. (Ed.). Springer, USA., ISBN: 978-1-4614-0652-5, pp: 205-221.
  133. Castellani, R.J., X. Zhu, A. Nunomura and G. Perry, 2012. Obituary: In memoriam: Mark A. Smith, PhD: Neuroscientist and visionary. UH Neurol. Inst. J., 5: 4-5.
  134. Castellani, R.J., P.I. Moreira, G. Perry and X. Zhu, 2012. The role of iron as a mediator of oxidative stress in Alzheimer disease. BioFactors, 38: 133-138.
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  135. Castellani, R.J. and G. Perry, 2012. Pathogenesis and Disease-modifying Therapy in Alzheimers Disease: The flat line of progress. Archives. Med. Res., 43: 694-698.
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  136. Candeias, E., A.I. Duarte, C. Carvalho, S.C. Correia and S. Cardoso et al., 2012. The impairment of insulin signaling in Alzheimer's disease. IUBMB Life, 64: 951-957.
  137. Candeias, E., A.I. Duarte, C. Carvalho, S.C. Correia and S. Cardoso et al., 2012. Pharmaceutical regulation: Crossroad of opportunity as the distinction between food and drugs blurs. IUBMB Life, 64: 951-957.
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  138. Calderon-Garciduenas, L., M. Kavanaugh, M. Block, A. D'Angiulli and R. Delgado-Chavez et al., 2012. Neuroinflammation, hyperphosphorylated tau, diffuse amyloid plaques and down-regulation of the cellular prion protein in air pollution exposed children and young adults. J. Alzheimer's Dis., 28: 93-107.
  139. Bonda, D.J., R.J. Castellani, H.G. Lee, M. Tabaton and G. Casadesus et al., 2012. Down Syndrome and Alzheimer Disease: A Multi-hit Hypothesis based on Multiple Contributing Factors resulting in Pleotrophic Consequences. In: Alzheimer's Disease Research Compendium, Sun, M.K. (Ed.). Nova Science Publishers, Hauppauge, New York, ISBN: 978-1-62257-511-4, pp: 183-193.
  140. Bonda, D.J., M.A. Smith, G. Perry, H.G. Lee, X. Wang and X. Zhu, 2012. R-α-Lipoic Acid as a Potent Agent of Mitochondrial Protection in Alzheimer's Disease. In: Mitochondrial Signaling in Health and Disease, Orrenius, S., L. Packer, E. Cadenas (Eds.). CRC Press, Boca Raton, Florida, pp: 455-467.
  141. Bonda, D.J., G. Liu, P. Men, G. Perry, M.A. Smith and X. Zhu, 2012. Nanoparticle delivery of transition-metal chelators to the brain: Oxidative stress will never see it coming! CNS Neurol. Disord. Drug Targets, 11: 81-85.
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  142. Ziats, N.P., R.B. Petersen, H.G. Lee, R.J. Castellani, G. Perry and X. Zhu, 2011. Mark A. Smith, 1965-2010: Consummate student of pathogenesis. Int. J. Clin. Exp. Pathol., 4: 731-732.
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  143. Zhu, X., R.J. Castellani, H.G. Lee, R.B. Petersen, A. Nunomura, M. Tabaton and G. Perry, 2011. The concept of redox balance in Alzheimer's disease: Mark Anthony Smith 1965-2010. Redox Rep., 16: 47-48.
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  144. Zhu, X., R.J. Castellani, H.G. Lee and G. Perry, 2011. The origin of oxidative stress in neurodegenerative disease: Mark Anthony smith 1965-2010. Free Radical Biol. Med., 51: 248-249.
  145. Wise-Scira, O., L. Xu, T. Kitahara, G. Perry and O. Coskuner, 2011. Amyloid-β peptide structure in aqueous solution varies with fragment size. J. Chem. Phys., Vol. 135. 10.1063/1.3662490.
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  146. Wang, X., M. Smith, G. Perry and X. Zhu, 2011. Mitochondrial fragmentation mediates MPP+ Toxicity in Neurons: Implications for Parkinson's disease. Microscopy Microanalysis, 17: 196-197.
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  147. Wang, X., B. Su, W. Liu, X. He and Y. Gao et al., 2011. DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: Implications for Parkinson's disease. Aging Cell, 10: 807-823.
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  148. Valdez, C.M., C.F. Phelix, M.A. Smith, G. Perry and F. Santamaria, 2011. Modeling cholesterol metabolism by gene expression profiling in the hippocampus. Mol. BioSyst., 7: 1891-1901.
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  149. Stone, J.G., S.L. Siedlak, M. Tabaton, A. Hirano and R.J. Castellani et al., 2011. The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies. J. Neuropathol. Exp. Neurol., 70: 578-587.
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  150. Rothenberg, K.G., S.L. Siedlak, H.G. Lee, X. Zhu, G. Perry and M.A. Smith, 2011. Neurodegenerative processes in Alzheimer's disease: An overview of pathogenesis with strategic biomarker potential. Future Neurol., 6: 173-185.
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  151. Phelix, C.F., R.G. LeBaron, D.J. Roberson, R.E. Villanueva and G. Villareal et al., 2011. Transcriptome-to-metabolome™ biosimulation reveals human hippocampal hypometabolism with age and Alzheimer's disease. Int. J. Knowl. Discovery Bioinf., 2: 1-18.
  152. Perry, G., X. Wang, M. Smith and X. Zhu, 2011. Mitochondrial abnormalities in alzheimer disease. Microscopy Microanalysis, 17: 200-201.
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  153. Perry, G., S. Mondragon-Rodriguez, A. Nunomura, X. Zhu, P.I. Moreira and M.A. Smith, 2011. Oxidative Stress and Balance in Neurodegenerative Diseases. In: Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders, Dickson, D.W. and R.O. Weller (Eds.). 2nd Edn., Blackwell Publishing Ltd., Oxford, UK., pp: 10-12.
  154. Perry, G., R.J. Castellani, N.P. Ziats, R.B. Petersen, H.G. Lee and X. Zhu, 2011. Mark A. Smith: Impresario of alzheimer. Alzheimer Dis. Assoc. Disord., 25: 369-370.
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  155. Perry, G., M.A. Smith, G. Casadesus, H.G. Lee, P.I. Moreira, R.J. Castellani and X. Zhu, 2011. Using biology to untie the Gordian knot of Alzheimer's disease. J. Alzheimers Dis., 23: S31-S32.
  156. Perry, G., 2011. Journal of Parkinson's disease-birth of JAD's new sister. J. Alzheimer's Dis., 25: 1-1.
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  157. Mondragon-Rodriguez, S., F. Garcia-Sierra, G. Casadesus, H.G. Lee and R.B. Petersen et al., 2011. Oxidative Stress and Alzheimer Disease: Mechanisms and Therapeutic Opportunities. In: Neurochemical Mechanisms in Disease, Blass, J.P. (Ed.). Springer, Philadelphia, pp: 607-631.
  158. Liu, Q., F. Xie, A. Alvarado-Diaz, M.A. Smith, P.I. Moreira, X. Zhu and G. Perry, 2011. Neurofilamentopathy in neurodegenerative diseases. Open Neurol. J., 5: 58-62.
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  159. Correia, S.C., S. Cardoso, R.X. Santos, C. Carvalho and M.S. Santos et al., 2011. New insights into the mechanisms of mitochondrial preconditioning-triggered neuroprotection. Curr. Pharm. Des., 17: 3381-3389.
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  160. Correia, S.C., R.X. Santos, G. Perry, X. Zhu, P.I. Moreira and M.A. Smith, 2011. Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease? Ageing Res. Rev., 10: 264-273.
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  161. Colom, L.V., M.T. Castaneda, S. Hernandez, G. Perry, S. Jaime and A. Touhami, 2011. Intrahippocampal amyloid-β(1-40) injections injure medial septal neurons in rats. Current Alzheimer Res., 8: 832-840.
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  162. Chang, J., S. Siedlak, P. Moreira, A. Nunomura and R.J. Castellani et al., 2011. Oxidative Stress in Alzheimer's Disease: A Critical Appraisal of the Causes and the Consequences. In: Studies on Experimental Models, Basu, S. and L. Wiklund (Eds.). Springer, Philadelphia, pp: 211-220.
  163. Chang, J., M. Pallas, X. Zhu, H.J. Kim and A. Camins et al., 2011. Unveiling the Switch from aging to Alzheimer's Disease with the Senescence-Accelerated Mouse Model. In: Handbook of Animal Models in Alzheimer's Disease, Casadesus, G., G. Perry and M.A. Smith (Eds.). Vol. 1, IOS Press, The Netherlands, pp: 39-48.
  164. Castellani, R.J., Y. Gupta, B. Sheng, S.L. Siedlak and P.L. Harris et al., 2011. A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: Parallels to stress granules. Lab. Invest., 91: 1777-1786.
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  165. Castellani, R.J., X. Zhu, A. Nunomura and G. Perry, 2011. In memoriam: Mark A. Smith, PhD: Neuroscientist and visionary. Neuropathology, 31: 458-459.
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  166. Castellani, R.J., X. Zhu and G. Perry, 2011. Mark A. Smith, PhD: Renegade scientist and visionary. J. Neuropathol. Exp. Neurol., 70: 495-497.
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  167. Castellani, R.J., X. Zhu and G. Perry, 2011. Foreword: Alzheimer's disease therapy: A moving target. Therapy, 8: 457-458.
  168. Castellani, R.J., S.L. Nugent, A.L. Morrison, X. Zhu and H.G. Lee et al., 2011. CD3 in Lewy pathology: Does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease. J. Neural Transm., 118: 23-26.
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  169. Castellani, R.J., R.K. Rolston, X. Zhu, R. Petersen and G. Perry, 2011. In memoriam: Mark A. Smith, PhD. Dis.-Month, 57: 524-526.
  170. Castellani, R.J., R.B. Petersen, H.G. Lee, X. Zhu and G. Perry, 2011. Obituary: Mark A. Smith: The scientist, the man. Int. J. Exp. Pathol., 92: 297-298.
  171. Castellani, R.J., M.W. Marlatt, A. Nunomura, P.I. Moreira and H.G. Lee et al., 2011. Thinking Outside the Box in Alzheimer Disease Treatment. In: Pharmaceutical Sciences Encyclopedia: Drug Discovery, Development and Manufacturing, Gad, S.C. (Ed.). John Wiley and Sons, New Jersey, pp: 929-941.
  172. Castellani, R.J., H.G. Lee, R.B. Petersen, X. Zhu and G. Perry, 2011. Pathological phenotype in familial neurodegenerative disease: Implications for families and therapeutic constructs. Therapy, 8: 475-479.
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  173. Castellani R.G., Perry, H.G. Lee and X. Zhu, 2011. Mark A. Smith: Scholar and innovator. Eur. J. Histochem., .
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  174. Casadesus, G., G. Perry and M.A. Smith, 2011. Advances in Alzheimer's Disease 1: Handbook of Animal Models in Alzheimer's Disease. IOS Press, Amsterdam, Netherlands., Pages: 340.
  175. Carvalho, C., S.C. Correia, R.X. Santos, S. Cardoso and P.I. Moreira et al., 2011. Association of Mitochondrial Signaling in Alzheimer's Disease and Hypoxia. In: Molecular Aspects of Neurodegeneration and Neuroprotection, Farooqui, A.A. and T. Farooqui (Eds.). Bentham Science Publishers Ltd., Sharjah, pp: 50-61.
  176. Britton, G.B., M.A. Smith, G. Perry, K. Sambamurti, K.S.J. Rao, 2011. Drug discovery for neurodegenerative diseases: Challenges and novel biochemical targets. J. Alzheimers Dis., 24: 1-2.
  177. Bonda, D.J., R.J. Castellani, X. Zhu, A. Nunomura, H.G. Lee, G. Perry and M.A. Smith, 2011. A novel perspective on tau in Alzheimer's disease. Curr. Alzheimer Res., 8: 639-642.
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  178. Bonda, D.J., M.A. Smith, G. Perry, H.G. Lee, X. Wang and X. Zhu, 2011. The mitochondrial dynamics of Alzheimer's disease and Parkinson's disease offer important opportunities for therapeutic intervention. Curr. Pharm. Design, 17: 3374-3380.
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  179. Bonda, D.J., H.G. Lee, J.A. Blair, X. Zhu, G. Perry and M.A. Smith, 2011. Role of metal dyshomeostasis in Alzheimer's disease. Metallomics, 3: 267-270.
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  180. Ashford, J.W., A. Salehi, A. Furst, P. Bayley and G.B. Frisoni et al., 2011. Imaging the Alzheimer brain. J. Alzheimers Dis., 26: 1-27.
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  181. Ashford, J.W., A. Rosen, M. Adamson, P. Bayley and O. Sabri et al., 2011. Advances in Alzheimer's Disease 2: Handbook of Imaging the Alzheimer Brain. IOS Press, Amsterdam, Netherlands, Pages: 808.
  182. Zou, W.Q., G. Puoti, X. Xiao, J. Yuan and L. Qing et al., 2010. Variably protease-sensitive prionopathy: A new sporadic disease of the prion protein. Ann. Neurol., 68: 162-172.
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  368. Castellani, R.J., B.A. Alexiev, D. Phillips, G. Perry and M.A. Smith, 2007. Microscopic Investigations in Neurodegenerative Diseases. In: Modern Research and Educational Topics in Microscopy, Mendez-Vilas, A. and J. Diaz (Eds.). Formatex Ltd., Badajoz, Spain, pp: 171-182.
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  370. Casadesus, G., M.A. Smith, S. Basu, J. Hua and D.E. Capobianco et al., 2007. Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease. Mol. Neurodegener., Vol. 2. 10.1186/1750-1326-2-2.
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  373. Bonda, D.J., K.M. Webber, S.L. Siedlak, G. Perry, R.P. Friedland and M.A. Smith, 2007. The pathology of alzheimer disease elicits an in vivo immunological response. Am. J. Immunol., 3: 10-14.
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  374. Bishop, G.M., M.A. Smith, J.C. LaManna, A.C. Wilson, G. Perry and C.S. Atwood, 2007. Iron homeostasis is maintained in the brain, but not the liver, following mild hypoxia. Redox Report, 12: 257-266.
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  377. Zhu, X., M.A. Smith, A. Babar, S.L. Siedlak and Q. Yang et al., 2006. LRRK2 in Lewy Bodies of Parkinson Disease and Dementia with Lewy Bodies. In: Alzheimer's Disease: New Advances, Iqbal , K., B. Winblad and J. Avila (Eds.). Medimond S.r.l., Bologna, Italy, pp: 229-232.
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  380. Zhu, X., A.K. Raina, G. Perry and M.A. Smith, 2006. Apoptosis in Alzheimer disease: A mathematical improbability. Curr. Alzheimer Res., 3: 393-396.
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  383. Webber, K.M., D.M. Stocco, G. Casadesus, R.L. Bowen and C.S. Atwood et al., 2006. Steroidogenic acute regulatory protein (StAR): Evidence of gonadotropin-induced steroidogenesis in Alzheimer disease. Mol. Neurodegener., Vol. 1. 10.1186/1750-1326-1-14.
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  384. Strocchi, P., M.A. Smith, G. Perry, E. Tamagno and O. Danni et al., 2006. Clusterin up-regulation following sub-lethal oxidative stress and lipid peroxidation in human neuroblastoma cells. Neurobiol. Aging, 27: 1588-1594.
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  385. Sparks, D.L., R. Friedland, S. Petanceska, B.G. Schreurs and J. Shi et al., 2006. Trace copper levels in the drinking water, but not zinc or aluminum influence CNS Alzheimer-like pathology. J. Nutr. Health Aging, 10: 247-254.
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  386. Smith, M.A., X. Zhu, H.G. Lee, P.L. Harris, A.E. Fortino, G. Perry and R.J. Castellani, 2006. Sequestration of p27 within the cytoplasm of cardiac myocytes in chronic ischemic heart disease: Pathogenic implications for ischemic cardiomyopathy. Age, 28: 85-91.
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  387. Smith, M.A., K.S.J. Rao and G. Perry, 2006. Foreword: Apoptotic mechanisms in neurodegenerative diseases. Curr. Alzheimer Res., 3: 267-267.
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  403. Nunomura, A., R.J. Castellani, H.G. Lee, P.I. Moreira, X. Zhu, G. Perry and M.A. Smith, 2006. Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream. Sci. Aging Knowledge Environ., 10.1126/sageke.2006.8.pe10.
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  408. Moreira, P.I., X. Zhu, M.A. Smith, G. Perry and A. Nunomura, 2006. Antioxidant Therapies in the Prevention and Treatment of Alzheimer disease. In: Oxidative Stress and Age-Related Neurodegeneration, Luo, Y. and L. Packer (Eds.). Taylor & Francis, Boca Raton, Florida, USA, pp: 131-145.
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  414. Liu, G., P. Men, P.L. Harris, R.K. Rolston, G. Perry and M.A. Smith, 2006. Nanoparticle iron chelators: A new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance. Neurosci. Lett., 406: 189-193.
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  415. Lee, H.G., X. Zhu, K.L. Drew, J.A. Joseph and A. Nunomura et al., 2006. Oxidative Adaptation in Aging and Alzheimer's Disease: The Roles of Amyloid and Tau. In: Molecular Interventions in Lifestyle-Related Diseases, Hiramatsu, M., T. Yoshikawa and L. Packer (Eds.). Taylor and Francis, Boca Raton, Florida, USA., pp: 117-125.
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  417. Lee, H.G., X. Zhu, A. Takeda, G. Perry and M.A. Smith, 2006. Emerging evidence for the neuroprotective role of alpha-synuclein. Exp. Neurol., 200: 1-7.
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  418. Lee, H.G., X. Zhu, A. Nunomura, G. Perry and M.A. Smith, 2006. Amyloid-β vaccination: Testing the amyloid hypothesis? Am. J. Pathol., 169: 738-739.
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  420. Lee, H.G., M.A. Smith, S.L. Richardson, G. Perry and R.B. Petersen, 2006. Oxidative Stress and Prion Protein Mutations. In: Alzheimer's Disease: New Advances, Iqbal, K., B. Winblad and J. Avila (Eds.). Medimond S.R.L., Bologna, Italy, pp: 377-380.
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  422. Lee, H.G., M. Ueda, X. Zhu, G. Perry and M.A. Smith, 2006. Failure of Cytoplasmic-Nuclear Transport in Alzheimer disease. In: Alzheimer's Disease: New Advances, Iqbal , K., B. Winblad and J. Avila (Eds.). Medimond S.r.l., Bologna, Italy, pp: 341-344.
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  427. Hasegawa, T., M. Matsuzaki-Kobayashi, A. Takeda, N. Sugeno and A. Kikuchi et al., 2006. α-Synuclein facilitates the toxicity of oxidized catechol metabolites: Implications for selective neurodegeneration in Parkinson's disease. FEBS Lett., 580: 2147-2152.
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  430. Dwyer, B.E., M.L. Stone, X. Zhu, G. Perry and M.A. Smith, 2006. Heme deficiency in Alzheimer's disease: a possible connection to porphyria. J. Biomed. Biotechnol., 10.1155/JBB/2006/24038.
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  431. D.A. Forero, G. Casadesus, G. Perry and H. Arboleda, 2006. Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms. J. Cell Mol. Med., 10: 796-805.
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  445. Zhu, X., G. Perry and M.A. Smith, 2005. Commentary: Insulin signaling, diabetes mellitus and risk of Alzheimer disease. J. Alzheimers Dis., 7: 81-84.
  446. Yuan, J., M. Kinter, J. McGeehan, G. Perry, G. Kneale, P. Gambetti and W.Q. Zou, 2005. Concealment of epitope by reduction and alkylation in prion protein. Biochem. Biophys. Res. Commun., 326: 652-659.
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  455. Santa-Maria, I., M.A. Smith, G. Perry, F. Hernandez, J. Avila and F.J. Moreno, 2005. Effect of quinones on microtubule polymerization: A link between oxidative stress and cytoskeletal alterations in Alzheimer's disease. Biochim. Biophys. Acta Mol. Basis Dis., 1740: 472-480.
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  457. Sahin, M., S.B. Karauzum, G. Perry, M.A. Smith and Y. Aliciguzel, 2005. Retinoic acid isomers protect hippocampal neurons from amyloid-β induced neurodegeneration. Neurotoxicity Res., 7: 243-250.
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  458. Reddy, V.P., M.R. Garrett, G. Perry and M.A. Smith, 2005. Carnosine: A versatile antioxidant and antiglycating agent. Science's SAGE KE, Vol. 2005. 10.1126/sageke.2005.18.pe12.
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  459. Rajendran, R., M. Ren, G. Casadesus, M.A. Smith and G. Perry et al., 2005. Nuclear microscopy of diffuse plaques in the brains of transgenic mice. Nucl. Instrum. Methods Phys. Res., Sect. B Beam Interact. Mater. Atoms, 231: 326-332.
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  461. Perry, G., R.P. Friedland, G.J. Petot, A. Nunomura, R.J. Castellani, Z. Kubat and M.A. Smith, 2005. Alzheimer as a Disease of Metabolic Demand: Benefits of Physical and Brain Exercise. In: Exercise and Diseases: Prevention Through Training, Radak, Z. (Ed.). Meyer and Meyer Sport Ltd., Oxford, UK., pp: 7-16.
  462. Perry, G. and M.A. Smith, 2005. Imaging in Alzheimer disease. Microsc. Res. Tech., 67: 113-217.
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  465. Moreira, P.I., M.A. Smith, X. Zhu, K. Honda, H. Lee, G. Aliev and G. Perry, 2005. Oxidative damage and Alzheimer's disease: are antioxidant therapies useful? Drug News Perspect., 18: 13-19.
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  466. Moreira, P.I., M.A. Smith, X. Zhu, A. Nunomura, R.J. Castellani and G. Perry, 2005. Oxidative stress and neurodegeneration. Ann. N.Y. Acad. Sci., 1043: 545-552.
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  471. Moreira, P.I., A. Nunomura, G.J. Petot, G. Aliev, M.A. Smith and G. Perry, 2005. Brain Metabolic Alterations are Early Signs in Alzheimer Disease Pathophysiology. In: Research and Practice in Alzheimer's Disease, Special Issue on Nutrition, Cognitive Decline and Aging, Vellas, B. and L.J. Fitten (Eds.). Serdi, Paris, France, pp: 61-65.
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  473. Liu, Q., M.A. Smith, J. Avila, J. DeBernardis and M. Kansal et al., 2005. Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radical Biol. Med., 38: 746-754.
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  476. Lin, D., H.G. Lee, Q. Liu, G. Perry, M.A. Smith and L.M. Sayre, 2005. 4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal. Chem. Res. Toxicol., 18: 1219-1231.
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  481. Dwyer, B.E., A. Takeda, X. Zhu, G. Perry and M.A. Smith, 2005. Ferric cycle activity and Alzheimer disease. Curr. Neurovasc. Res., 2: 261-267.
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  482. Castellani, R.J., S.L. Siedlak, A.E. Fortino, G. Perry, B. Ghetti and M.A. Smith, 2005. Chitin-like polysaccharides in Alzheimer's disease brains. Current Alzheimer Res., 2: 419-423.
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  483. Castellani, R.J., D.A. DeWitt, G. Perry and M.A. Smith, 2005. Involvement of complex carbohydrate chemistry in Alzheimer disease. Med. Hypotheses. Res., 2: 393-400.
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  484. Casadesus, G., M.A. Smith and G. Perry, 2005. Commentary: Ceramide and cholesterol: Possible connections between normal aging of the brain and Alzheimer's disease. Just hypotheses or molecular pathways to be identified? Alzheimers Dementia, 1: 51-52.
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  486. Baykal, A., F.S. Arigul, G. Suleymanlar, P.I. Moreira, G. Perry, M.A. Smith and Y. Aliciguzel, 2005. Ciprofloxacin does not exert nephrotoxicity in rats. Am. J. Infect. Dis., 1: 145-148.
  487. Barbeito, L, J. Chun, L.I. Binder, V.M. Neto, G. Perry, C. Scazzochio and G. Violini, 2005. The end of a Chilean institute (Letter). Sci., 308: 792-793.
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  489. Aliyev, A., S.G. Chen, D. Seyidova, M.A. Smith, G. Perry, J. de la Torre and G. Aliev, 2005. Mitochondria DNA deletions in atherosclerotic hypoperfused brain microvessels as a primary target for the development of Alzheimer's disease. J. Neurol. Sci., 229: 285-292.
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  491. Zhu, X., M.A. Smith, G. Perry and G. Aliev, 2004. Mitochondrial failures in Alzheimer's disease. Am. J. Alzheimers Dis. Demen, 19: 345-352.
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  492. Zhu, X., K.M. Webber, G. Casadesus, A.K. Raina and H.G. Lee et al., 2004. Mitotic and gender parallels in Alzheimer disease: Therapeutic opportunities. Curr. Drug Targets, 5: 559-563.
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  497. Zhu, X., A.K. Raina, G. Perry and M.A. Smith, 2004. Alzheimer's disease: The two-hit hypothesis. Lancet Neurol., 3: 219-226.
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  498. Zhu, X., A. McShea, P.L.R. Harris, A.K. Raina and R.J. Castellani et al., 2004. Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease. J. Neurosci. Res., 75: 698-703.
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  499. Webber, K.M., R. Bowen, G. Casadesus, G. Perry, C.S. Atwood and M.A. Smith, 2004. Gonadotropins and Alzheimer's disease: The link between estrogen replacement therapy and neuroprotection. Acta Neurobiol. Exp., 64: 113-118.
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  500. Webber K.M., R. Bowen, G. Casadesus, G. Perry, C.S. Atwood and M.A. Smith, 2004. Gonadotropins and Alzheimer's disease: the link between estrogen replacement therapy and neuroprotection. Acta Neurobiol. Exp., 64: 113-118.
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  502. Smith, M.A., P.I. Moreira, R.J. Castellani and G. Perry, 2004. Amyloid-β: A multifaceted protein, Parts I and II. Brain Pathol., 14: 425-452.
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  504. Sayre, L.M., P.L.R. Harris, G. Perry and M.A Smith, 2004. In situ Localization of Nonenzymatic Peroxidase-Like Activity of Tissue-Bound Transition Metals. In: Current Protocols in Toxicology, Maines, M.D., L.G. Costa, E. Hodgson, D.J. Reed and I.G. Sipes (Eds.). John Wiley & Sons, Inc., Hoboken, New Jersey, pp:17.4.1-17.4.8.
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  507. Nunomura, A., S. Chiba, A. Takeda, M.A. Smith and G. Perry, 2004. Oxidative Stress in Alzheimer Disease: The Earliest Cytological and Biochemical Feature. In: Molecular Neurobiology of Alzheimer Disease and Related Disorders, Takeda, M., T. Tanaka and R. Cacabelos (Eds.). Karger, Basel, Switzerland, pp: 64-171.
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  511. Martin, A., M.A. Smith, G. Perry and J. Joseph, 2004. Nutritional Antioxidants, Vitamins, Cognition, and Neurodegenerative Disease. In: Principles of Gender-Specific Medicine, Legato, M.L.(Ed.)., Elsevier Academic Press, San Diego, California, pp: 813-823.
  512. Marlatt, M., H.G. Lee, G. Perry, M.A. Smith and X. Zhu, 2004. Sources and mechanisms of cytoplasmic oxidative damage in Alzheimer's disease. Acta Neurobiol. Exp., 64: 81-88.
  513. Liu, T., G. Perry, H.W. Chan, G. Verdile, R.N. Martins, M.A. Smith and C.S. Atwood, 2004. Amyloid-β-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression. J. Neurochem., 88: 554-563.
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  514. Liu, Q., F. Xie, S.L. Siedlak, A. Nunomura and K. Honda et al., 2004. Neurofilament proteins in neurodegenerative diseases. Cell. Mol. Life Sci., 61: 3057-3075.
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  517. Lee, H.G., O. Ogawa, X. Zhu, M.J. O'Neill and R.B. Petersen et al., 2004. Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease. Acta Neuropathol., 107: 365-371.
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  518. Lee, H.G., G. Casadesus, X. Zhu, J.A. Joseph, G. Perry and M.A. Smith, 2004. Perspectives on the amyloid-β cascade hypothesis. J. Alzheimers Dis., 6: 137-145.
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  519. Lee, H.G., G. Casadesus, X. Zhu, A. Takeda, G. Perry and M.A. Smith, 2004. Challenging the amyloid cascade hypothesis: Senile plaques and amyloid-β as protective adaptations to Alzheimer disease. Ann. N. Y. Acad. Sci., 1019: 1-4.
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  521. Johnson, G.P., A.K. Raina, M.L. Cohen and M.A. Smith, 2004. When hypotheses dominate: Established ideas can strangle the assessment of valid alternatives. Scientist, 18: 6-7.
  522. Honda, K., S. Shimohama, M.A. Smith and G. Perry, 2004. Comment: Role of redox-active iron in Alzheimer's disease. Curr. Med. Lit-Neurol., 20: 25-30.
  523. Honda, K., Q. Liu, G. Perry and M.A. Smith, 2004. Comment: Is redox regulation of development in caenorhabditis elegans a critical issue? Alzheimer Res. Forum. .
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  527. Gomez-Ramos, A., M.A. Smith, G. Perry and J. Avila, 2004. Tau phosphorylation and assembly. Acta Neurobiol. Exp., 64: 33-39.
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  528. Ghanbari, H.A., K. Ghanbari, P.L. Harris, P.K. Jones and Z. Kubat et al., 2004. Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients. Aging Cell, 3: 41-44.
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  529. Dwyer, B.E., A.K. Raina, G. Perry and M.A. Smith, 2004. Homocysteine and Alzheimer's disease: A modifiable risk? Free Radical Biol. Med., 36: 1471-1475.
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  530. Dozza, B., M.A. Smith, G. Perry, M. Tabaton and P. Strocchi, 2004. Regulation of glycogen synthase kinase-3β by products of lipid peroxidation in human neuroblastoma cells. J. Neurochem., 89: 1224-1232.
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  531. De la Torre, J., G. Aliev, G. Perry, T.E. Finucane, M.A. Meyer and J.L. Cummings, 2004. Drug therapy in Alzheimer's disease. N. Engl. J. Med., 351: 1911-1913.
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  532. Castellani, R.J., M.A. Smith, G. Perry and R.P. Friedland, 2004. Cerebral amyloid angiopathy: Major contributor or decorative response to Alzheimer's disease pathogenesis. Neurobiol. Aging, 25: 599-602.
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  533. Castellani, R.J., K. Honda, X. Zhu, A.D. Cash, A. Nunomura, G. Perry and M.A. Smith, 2004. Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease. Ageing Res. Rev., 3: 319-326.
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  534. Castellani, R.J., G. Perry and M.A. Smith, 2004. Prion disease and Alzheimer's disease: Pathogenic overlap. Acta Neurobiol. Exp., 64: 11-17.
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  535. Cash A.D., M.A. Smith and G. Perry, 2004. Oxidative stress mechanisms and potential therapeutic modalities in alzheimer disease. Med. Chem. Rev. Online, 1: 19-23.
  536. Casadesus, G., X. Zhu, C.S. Atwood, K.M. Webber, G. Perry, R.L. Bowen and M.A. Smith, 2004. Beyond estrogen: Targeting gonadotropin hormones in the treatment of Alzheimers disease. Curr. Drug Targets CNS Neurol. Disorders, 3: 281-285.
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  537. Casadesus, G., M.A. Smith, X. Zhu, G. Aliev and A.D. Cash et al., 2004. Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species. J. Alzheimers Dis., 6: 168-169.
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  538. Casadesus, G., G. Perry, J.A. Joseph and M.A. Smith, 2004. Eat less, Eat Better, and Live Longer: Does It Work and is It Worth It?The Role of Diet in Aging and Disease. In: The Fountain of Youth: Cultural, Scientific, and Ethical Perspectives on a Biomedical Goal, Post, S.G. and R.H. Binstock (Eds.). Oxford University Press, New York, pp: 201-227.
  539. Bowen, R.L., G. Verdile, T. Liu, G. Perry, M.A. Smith, R.N. Martins and C.S. Atwood, 2004. Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-β precursor protein and amyloid-β deposition. J. Biol. Chem., 279: 20539-20545.
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  540. Bowen, R., C.S. Atwood, G. Perry and M.A. Smith, 2004. Mechanisms Involved In Gender Differences In Alzheimer's Disease: The Role of Leuteinizing [SIC] and Follicle Stimulating Hormones. In: Principles of Gender-Specific Medicine, Legato, M.L.(Ed.)., Elsevier Academic Press, San Diego, California, pp: 1234-1237.
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  542. Atwood, C.S., G. Perry, H. Zeng, Y. Kato and W.D. Jones et al., 2004. Copper mediates dityrosine cross-linking of Alzheimer's amyloid-β. Biochemistry, 43: 560-568.
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  543. Aliyev, A., D. Seyidova, N. Rzayev, M.E. Obrenovich and B.T. Lamb et al., 2004. Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease. Neurol., Res., 26: 547-553.
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  544. Aliev, G., R.J. Castellani, R.B. Petersen, G. Burnstock, G. Perry and M.A. Smith, 2004. Pathobiology of familial hypercholesterolemic atherosclerosis. J. Submicrosc. Cytol. Pathol., 36: 225-240.
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  546. Zhu, X., Z. Sun, H.G. Lee, S.L. Siedlak, G. Perry and M.A. Smith, 2003. Distribution, levels and activation of MEK1 in Alzheimer's disease. J. Neurochem., 86: 136-142.
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  547. Zhu, X., O. Ogawa, Y. Wang, G. Perry and M.A. Smith, 2003. JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease. J. Neurochem., 85: 87-93.
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  548. Zhu, X., G. Perry and M.A. Smith, 2003. Amyotrophic lateral sclerosis: A novel hypothesis involving a gained loss of function in the JNK/SAPK pathway. Redox Report, 8: 129-133.
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  549. Zhu, X., A.K. Raina, H.G. Lee, M. Chao and A. Nunomura et al., 2003. Oxidative stress and neuronal adaptation in Alzheimer disease: The role of SAPK pathways. Antioxidants Redox Signal., 5: 571-576.
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  550. Veurink, G., D. Liu, K. Taddei, G. Perry and M.A. Smith et al., 2003. Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants. Free Radicals Biol. Med., 34: 1070-1077.
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  551. Tateyama, M., A. Takeda, Y. Onodera, M. Matsuzaki and T. Hasegawa et al., 2003. Oxidative stress and predominant Aβ42 (43) deposition in myopathies with rimmed vacuoles. Acta Neuropathol., 105: 581-585.
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  553. Taddeo, M.A., M.A. Smith, Q. Liu, C.S. Atwood, L.M. Sayre and G. Perry, 2003. Metal-Catalyzed Redox Activity in Neurodegenerative Disease. In: Metal Ions and Neurodegenerative Disorders, Zatta, P. (Ed.). World Scientific Publishing Co., Singapore, pp: 1-14.
  554. Smith, M.A., G. Perry, C.S. Atwood and R.L. Bowen, 2003. Estrogen replacement and risk of Alzheimer disease. JAMA, 289: 1100-1100.
  555. Raina, A.K., X. Zhu, S. Shimohama, G. Perry and M.A. Smith, 2003. Tipping the apoptotic balance in Alzheimer's disease: The abortosis concept. Cell Biochem. Biophys., 39: 249-255.
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  556. Raina, A.K., A. Hochman, H. Ickes, X. Zhu and O. Ogawa et al., 2003. Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out? Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 27: 251-254.
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  557. Raina A.K., X. Zhu, G. Perry and M.A. Smith, 2003. Comment: How to die? Alzheimer Res. Forum, .
  558. Perry, G., R.J. Castellani, M.A. Smith, P.L. Harris and Z. Kubat et al., 2003. Oxidative damage in the olfactory system in Alzheimer's disease. Acta Neuropathol., 106: 552-556.
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  559. Perry, G., R. Srinivas, A. Nunomura and M.A. Smith, 2003. The Role of Oxidative Mechanisms in Neurodegenerative Diseases. In: Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders, Dickson, D.C. (Ed.). ISN Neuropath Press, Basel, Switzerland, pp: 8-10.
  560. Perry, G., M.A. Taddeo, R.B. Petersen, R.J. Castellani and P.L.R. Harris et al., 2003. Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease. Biometals, 16: 77-81.
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  561. Perry, G., A.K. Raina, A. Nunomura, H.G. Lee and X. Zhu et al., 2003. Oxidative Stress and the Pathogenic Mechanism of Alzheimer Disease. In: Alzheimer's Disease and Related Disorders: Research Advances, Iqbal, K. and B. Winblad (Eds.). Ana Aslan International Academy of Aging, Bucharest, Hungary, pp: 425-432.
  562. Perry, G., A. Raina, M.A. Smith and X. Zhu, 2003. Comment: Oncogenic processes in Alzheimer's disease: A common link? Alzheimer Res. Forum. .
  563. Perry, G., A. Nunomura, A.K. Raina, G. Aliev and S.L. Siedlak et al., 2003. A metabolic basis for Alzheimer disease. Neurochem. Res., 28: 1549-1552.
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  564. Ogawa, O., X. Zhu, H.G. Lee, A. Raina and M.E. Obrenovich et al., 2003. Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: A mitotic catastrophe? Acta Neuropathol., 105: 524-528.
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  565. Ogawa, O., H.G. Lee, X. Zhu, A. Raina and P.L. Harris et al., 2003. Increased p27, an essential component of cell cycle control, in Alzheimer's disease. Aging Cell, 2: 105-110.
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  566. Nunomura, A., S. Chiba, M.A. Smith and G. Perry, 2003. Oxidative damage and amyloid β deposition in the brains of Alzheimer's disease (Japanese). Proc. Ann. Meet. Japanese Res. Group Senile Dementia, 13: 43-45.
  567. Nunomura, A., S. Chiba, M.A. Smith and G. Perry, 2003. Alzheimer's disease and oxidative stress (Japanese). Proc. Ann. Meet. Japanese Res. Group Senile Dementia, 13: 83-85.
  568. Matsubara, E., T. Bryant-Thomas, J.P. Quinto, T.L. Henry and B. Poeggeler et al., 2003. Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease. J. Neurochem., 85: 1101-1108.
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  569. Liu, Q., A.K. Raina, M.A. Smith, L.M. Sayre and G. Perry, 2003. Hydroxynonenal, toxic carbonyls and Alzheimer disease. Mol. Aspects Med., 24: 305-313.
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  570. Lee, H.G., X. Zhu, R.B. Petersen, G. Perry and M.A. Smith, 2003. Amyloids, aggregates and neuronal inclusions: Good or bad news for neurons? Curr. Med. Chem. Immunol. Endocrine Metab. Agents, 3: 293-298.
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  571. Lee, H.G., R.B. Petersen, X. Zhu, K. Honda, G. Aliev, M.A. Smith and G. Perry, 2003. Will preventing protein aggregates live up to its promise as prophylaxis against neurodegenerative diseases? Brain Pathol., 13: 630-638.
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  572. Lee H.G., X. Zhu, K.M. Webber, A.K. Raina, G. Perry and M.A. Smith, 2003. Comment: Are two hits required for AD? Oxidative stress and cell cycle reentry. Alzheimer Res. Forum. .
  573. Kitamura, Y., D. Tsuchiya, K. Takata, K. Shibagaki and T. Taniguchi et al., 2003. Possible involvement of wiskott-aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease. Neurosci. Lett., 346: 149-152.
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  574. Gomez-Ramos, A., J. Diaz-Nido, M.A. Smith, G. Perry and J. Avila, 2003. Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells. J. Neurosci. Res., 71: 863-870.
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  575. Dong, J., C.S. Atwood, V.E. Anderson, S.L. Siedlak, M.A. Smith, G. Perry and P.R. Carey, 2003. Metal binding and oxidation of amyloid-β within isolated senile plaque cores: Raman microscopic evidence. Biochemistry, 42: 2768-2773.
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  576. Chao, M., X. Zhu, A.K. Raina, G. Aliev and A. Takeda et al., 2003. Sources contributing to the initiation and propagation of oxidative stress in Alzheimer disease. Proc. Indian Natl. Sci. Acad. B, 69: 251-260.
  577. Cash, A.D., R. Srinivas, C.A. Rottkamp, X. Zhu and M.A. Taddeo et al., 2003. Metal Homeostasis and Its Relation to Oxidative Stress in Alzheimer's Disease. In: Redox-Genome Interactions in Health and Disease, Fuchs, J., L. Packer and M. Podda (Eds.). Marcel Dekker, New York, USA., pp: 425-437.
  578. Cash, A.D., G. Aliev, S.L. Siedlak, A. Nunomura and H. Fujioka et al., 2003. Microtubule reduction in Alzheimer's disease and aging is independent of τ filament formation. Am. J. Pathol., 162: 1623-1627.
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  579. Bruckner, S.R., G. Perry and S. Estus, 2003. 4-hydroxynonenal contributes to NGF withdrawal-induced neuronal apoptosis. J. Neurochem., 85: 999-1005.
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  580. Bianco, N.R., G. Perry, M.A. Smith, D.J. Templeton and M.M. Montano, 2003. Functional implications of antiestrogen induction of quinone reductase: Inhibition of estrogen-induced deoxyribonucleic acid damage. Mol. Endocrinol., 17: 1344-1355.
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  581. Atwood, C.S., R.L. Bowen, M.A. Smith and G. Perry, 2003. Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply. Brain Res. Rev., 43: 164-178.
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  582. Atwood, C.S., M.E. Obrenovich, T. Liu, H. Chan, G. Perry, M.A. Smith and R.N. Martins, 2003. Amyloid-β: A chameleon walking in two worlds: A review of the trophic and toxic properties of Amyloid-β. Brain Res. Rev., 43: 1-16.
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  583. Atwood, C.S., M.A. Smith, R.N. Martins, R.E. Tanzi, A.E. Roher, A.I. Bush and G. Perry, 2003. Neuroinflammatory Environments Promote Amyloid-β Deposition and Posttranslational Modification. In: Neuroinflammation: Mechanisms and Management, Wood, P.L. (Ed.). 2nd Edn., Humana Press, Totowa, NJ., USA., pp: 249-266.
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  584. Atwood, C.S., G. Perry, M.A. Smith, M. Pfeifer and S. Boncristiano et al., 2003. Cerebral hemorrhage and Amyloid-beta. Science, 299: 1014-1014.
  585. Atwood, C.S., G. Perry and M.A. Smith, 2003. Cerebral hemorrhage and amyloid-β. Science, Vol. 299. .
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  586. Atwood, C., G. Bishop, G. Perry and M.A. Smith, 2003. Comment: Chelation, metals and Parkinson's disease. Alzheimer Res. Forum, .
  587. Atwood C., G. Perry, M.A. Smith and K. Webber, 2003. Comment: chelation as a therapeutic for neurodegenerative diseases. Alzheimer Res. Forum, .
  588. Atwood C., G. Casadesus, G. Perry and M.A. Smith, 2003. Comment: Coping with copper-minute amount of metal plagues rabbit brain. Alzheimer Res. Forum. .
  589. Aliev, G., M.E. Obrenovich, M.A. Smith and G. Perry, 2003. Hypoperfusion, mitochondria failure, oxidative stress and Alzheimer disease. BioMed. Res. Int., 3: 162-163.
  590. Aliev, G., M.E. Obrenovich, D. Seyidova, N.M. Rzayev and A.S. Aliyev et al., 2003. X-ray contrast media induce aortic endothelial damage, which can be prevented with prior heparin treatment. J. Submicrosc. Cytol. Pathol., 35: 253-266.
  591. Aliev, G., M.A. Smith, M.E. Obrenovich, C. Jack and G. Perry, 2003. Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Alzheimer disease. Neurotoxicity Res., 5: 491-504.
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  592. Aliev, G., M.A. Smith, J. De La Torre J and G. Perry, 2003. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. In: Third International Congress on Vascular Dementia, Korczyn, A.D., (Ed.). Monduzzi Editore, Bologna, Italy, pp: 9-20.
  593. Aliev, G., G. Perry and M.A. Smith, 2003. Comment: focus on the mitochondrion in neurodegenerative disease. Alzheimer Res. Forum. .
  594. Aliev, G., D. Seyidova, B.T. Lamb, M.E. Obrenovich and S.L. Siedlak et al., 2003. Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice. Neurol. Res., 25: 665-674.
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  595. Aliev, G., D. Seyidova, A.K. Raina, M.E. Obrenovich and M.L. Neal et al., 2003. Vascular hypoperfusion, mitochondria failure and oxidative stress in Alzheimer disease. Proc. Indian Natl. Sci. Acad. B. Biol. Sci., 69: 209-238.
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  596. Zhu, X., H.G. Lee, A.K. Raina, G. Perry and M.A. Smith, 2002. The role of mitogen-activated protein kinase pathways in Alzheimer's disease. Neurosignals, 11: 270-281.
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  597. Zhu, X., G. Perry and M.A. Smith, 2002. Oxidative Stress and Cell Signaling in Alzheimer Disease. In: XI Biennial Meeting of the Society for Free Radical Research International, Pasquier, C. (Ed.). Monduzzi Editore, Bologna, Italy, pp: 333-341.
  598. Zhang, J., T.J. Montine, M.A. Smith, S.L. Siedlak, G. Gu, D. Robertson and G. Perry, 2002. The mitochondrial common deletion in Parkinson's disease and related movement disorders. Parkinsonism Relat. Disord., 8: 165-170.
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  599. Wataya, T., A. Nunomura, M.A. Smith, S.L. Siedlak and P.L.R. Harris et al., 2002. High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. J. Biol. Chem., 277: 4644-4648.
  600. Tamagno, E., P. Bardini, A. Obbili, A. Vitali and R. Borghi et al., 2002. Oxidative stress increases expression and activity of BACE in NT2 neurons. Neurobiol. Dis., 10: 279-288.
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  601. Takeda, A., Y. Itoyama, T. Kimpara, R.K. Kutty and N.G. Abraham et al., 2002. Role of Heme Catabolism in Neurodegenerative Diseases. In: Heme Oxygenase in Biology and Medicine, Abraham, N.G., J. Alam and K. Nath (Eds.). Kluwer Academic/Plenum Publishers, New York, pp: 135-143.
  602. Takeda, A., Y. Itoyama, T. Kimpara, R.K. Kutty and N.G.Abraham et al., 2002. Role of Heme Catabolism in Neurodegenerative Diseases. In: Heme Oxygenase in Biology and Medicine, Abraham, N.G. (Ed.)., Plenum Publishers, New York, pp:135-143.
  603. Takata, K., Y. Kitamura, J. Kakimura, K. Shibagaki and T. Taniguchi et al., 2002. Possible protective mechanisms of heme oxygenase-1 in the brain. Ann. N. Y. Acad. Sci., 977: 501-506.
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  604. Smith, M.A., X. Zhu and G. Perry, 2002. Signal transduction in Alzheimer`s disease. Neurosignals, 11: 235-298.
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  605. Smith, M.A., K.L. Drew, A. Nunomura, A. Takeda and K. Hirai et al., 2002. Amyloid-β, tau alterations and mitochondrial dysfunction in Alzheimer disease: The chickens or the eggs? Neurochem. Int., 40: 527-531.
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  606. Smith, M.A., J.A. Joseph, C.S. Atwood and G. Perry, 2002. Dangers of the amyloid-β vaccination. Acta Neuropathol., 104: 110-110.
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  607. Smith, M.A., G. Perry and W.A. Pryor, 2002. Causes and consequences of oxidative stress in Alzheimer's disease. Free Radic. Biol. Med., 32: 1049-1083.
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  608. Smith, M.A., G. Casadesus, J.A. Joseph and G. Perry, 2002. Amyloid-β and τ serve antioxidant functions in the aging and Alzheimer brain Free Radic. Biol. Med., 33: 1194-1199.
  609. Smith, M.A., C.S. Atwood, J.A. Joseph and G. Perry, 2002. Predicting the failure of amyloid-β vaccine. Lancet, 359: 1864-1865.
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  610. Smith, M.A., C.S. Atwood, J.A. Joseph and G. Perry, 2002. Ill-fated amyloid-β vaccine. J. Neurosci. Res., 69: 285-285.
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  611. Shi, J., G. Perry, M.S. Berridge, G. Aliev and S.L. Siedlak et al., 2002. Labeling of cerebral amyloid β deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice. J. Nucl. Med., 43: 1044-1051.
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  612. Rottkamp, C.A., C.S. Atwood, J.A. Joseph, A. Nunomura, G. Perry and M.A. Smith, 2002. The state versus amyloid-β: The trial of the most wanted criminal in Alzheimer disease. Peptides, 23: 1333-1341.
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  613. Rottkamp, C.A., C.S. Atwood, G. Perry and M.A. Smith, 2002. The state versus amyloid-β: The trial of the most wanted criminal in Alzheimer disease. Peptide, 23: 1333-1341.
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  614. Reddy, V.P., M.E. Obrenovich, C.S. Atwood, G. Perry and M.A. Smith, 2002. Involvement of Maillard reactions in Alzheimer disease. Neurotoxicity Res., 4: 191-209.
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  615. Raina, A.K., L.M. Sayre, C.S. Atwood, C.A. Rottkamp and A. Hochman et al., 2002. Apoptotic and Oxidative Indicators in Alzheimer's Disease. In: Neuromethods, Volume 37: Apoptosis Techniques and Protocols, LeBlanc, A.C. (Ed.). 2nd Edn., Humana Press, Inc., Totowa, New Jersey, pp: 225-246.
  616. Raina, A.K., C.A. Rottkamp, X. Zhu, O. Ogawa and A. Hochman et al., 2002. Neuronal Survival and Death in Alzheimer Disease. In: Mapping the Progress of Alzheimer's and Parkinson's Disease, Mizuno, Y., A. Fisher and I. Hanin (Eds.). Plenum Publishers, New York, pp: 49-57.
  617. Raina A.K., G. Perry, X. Zhu and M.A. Smith, 2002. Comment: harlequin and alzheimer disease: remarkable parallels. Alzheimer Res. Forum, .
  618. Perry, G., M.A. Taddeo, A. Nunomura, X. Zhu and T. Zenteno-Savin et al., 2002. Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: Beyond damage and response. Comp. Biochem. Physiol. C Toxicol. Pharmacol., 133: 507-513.
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  619. Perry, G., L.M. Sayre, C.S. Atwood, R.J. Castellani, A.D. Cash, C.A. Rottkamp and M.A. Smith, 2002. The role of iron and copper in the aetiology of neurodegenerative disorders. CNS Drugs, 16: 339-352.
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  620. Perry, G., A.D. Cash, R. Srinivas and M.A. Smith, 2002. Metals and oxidative homeostasis in Alzheimer's disease. Drug Dev. Res., 56: 293-299.
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  621. Perry, G., A.D. Cash and M.A. Smith, 2002. Alzheimer disease and oxidative stress. BioMed Res. Int., 2: 120-123.
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  622. Perry, G., A. Nunomura, K. Hirai, X. Zhu and M. Prez et al., 2002. Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radical Biol. Med., 33: 1475-1479.
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  623. Perry, G., A. Nunomura, A.D. Cash, M.A. Taddeo and K. Hirai et al., 2002. Reactive oxygen: Its sources and significance in Alzheimer disease. J. Neural Transmission, 62: 69-75.
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  624. Perry, G. and M.A. Smith, 2002. Neurodegenerative Disease: Role of Free Radical Damage, In: Research and Practice in Alzheimer's Disease, Vellas, B., L.J. Fitten, B. Winblad, H. Feldman, M. Grundman, E. Giacobini and A. Kurz (Eds.). Serdi Publisher, France, pp: 287-290.
  625. Perry, G. and M.A. Smith, 2002. Comment: New parkinson's gene: dj mutations make neurons change their tune. Alzheimer Res. Forum. .
  626. Perez, M., F. Hernandez, A. Gomez-Ramos, M. Smith, G. Perry and J. Avila, 2002. Formation of aberrant phosphotau fibrillar polymers in neural cultured cells. Eur. J. Biochem., 269: 1484-1489.
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  627. Pappolla, M.A., M.J. Simovich, T. Bryant-Thomas, Y.J. Chyan and B. Poeggeler et al., 2002. The neuroprotective activities of melatonin against the Alzheimer β-protein are not mediated by melatonin membrane receptors. J. Pineal Res., 32: 135-142.
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  628. Pappolla, M.A., M.A. Smith, T. Bryant-Thomas, N. Bazan and S. Petanceska et al., 2002. Cholesterol, oxidative stress and Alzheimer`s disease: Expanding the horizons of pathogenesis. Free Radic. Biol. Med., 33: 173-181.
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  629. Ogawa, O., X. Zhu, G. Perry and M.A. Smith, 2002. Mitochondrial abnormalities and oxidative imbalance in neurodegenerative disease. Sci. Aging Knowledge Environ. .
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  630. Ogawa O., G. Perry and M.A. Smith, 2002. The down's side of mitochondria. Dev. Cell., 2: 255-256.
  631. Obrenovich M.E., J.A. Joseph, C.S. Atwood, G. Perry and M.A. Smith, 2002. Commentary: Amyloid-β: A (life) preserver for the brain. Neurobiol. Aging, 23: 1097-1099.
  632. Nunomura, A., S. Chiba, K. Kosaka, A. Takeda, R.J. Castellani, M.A. Smith and G. Perry, 2002. Neuronal RNA oxidation is a prominent feature of dementia with lewy bodies. Neurorep., 13: 2035-2039.
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  633. Lee, H.G, X. Zhu, H.A. Ghanbari, O. Ogawa and A.K. Raina et al., 2002. Differential regulation of glutamate receptors in Alzheimer's disease. Neurosignals, 11: 282-292.
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  634. Kikuchi, A., A. Takeda, H. Onodera, T. Kimpara and K. Hisanaga et al., 2002. Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy. Neurobiol. Dis., 9: 244-248.
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  635. Kakimura, J.I., Y. Kitamura, K. Takata, M. Umeki and S. Suzuki et al., 2002. Microglial activation and amyloid-β- clearance induced by exogenous heat-shock proteins. FASEB. J., 16: 601-603.
  636. Kakimura, J., Y. Kitamura, K. Takata, D. Tsuchiya and T. Taniguchi et al., 2002. Possible involvement of ER chaperone Grp78 on reduced formation of amyloid‐β deposits. Ann. N. Y. Acad. Sci., 977: 327-332.
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  637. Hartzler, A.W., X. Zhu, S.L. Siedlak, R.J. Castellani, J. Avila, G. Perry and M.A. Smith, 2002. The p38 pathway is activated in pick disease and progressive supranuclear palsy: A mechanistic link between mitogenic pathways, oxidative stress and tau. Neurobiol. Aging, 23: 855-859.
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  638. Guentchev, M., S.L. Siedlak, C. Jarius, F. Tagliavini and R.J. Castellani et al., 2002. Oxidative damage to nucleic acids in human prion disease. Neurobiol. Dis., 9: 275-281.
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  639. Drew, K.L., O. Toien, P.M. Rivera, M.A. Smith, G. Perry and M.E. Rice, 2002. Role of the antioxidant ascorbate in hibernation and warming from hibernation. Comp. Biochem. Physiol. C Toxicol. Pharmacol., 133: 483-492.
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  640. Clapp-Lilly, K.L., M.A. Smith, G. Perry, P.L. Harris, X. Zhu, K.L. Drew and L.K. Duffy, 2002. Melatonin exhibits antioxidant properties in a mouse brain slice model of excitotoxicity. Int. J. Circumpolar Health, 61: 32-40.
  641. Castellani, R.J., G. Perry, S.L. Siedlak, A. Nunomura and S. Shimohama et al., 2002. Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans. Neurosci. Lett., 319: 25-28.
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  642. Castellani, R.J., C.S. Atwood, G. Perry, R.B. Petersen and M.A. Smith, 2002. Prion and Alzheimer Diseases: The Road to Pathogenesis is Paved with Copper. In: Prion Diseases and Copper Metabolism: BSE, Scrapie and CJD Research, Brown, D.R. (Ed.)., Horwood Publishing, Chichester, United Kingdom, pp: 96-101, 195-250.
  643. Castellani, R., K. Hirai, G. Aliev, K.L. Drew and A. Nunomura et al., 2002. Perspective: Role of mitochondrial dysfunction in Alzheimer's disease. J. Neurosci. Res., 70: 357-360.
  644. Cash, A.D., G. Perry, O. Ogawa, A.K. Raina, X. Zhu and M.A. Smith, 2002. Is Alzheimer's disease a mitochondrial disorder? Neuroscientist, 8: 489-496.
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  645. Cash, A.D., G. Perry and M.A. Smith, 2002. Therapeutic potential in Alzheimer disease. Curr. Med. Chem., 9: 1605-1610.
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  646. Bowen, R.L., M.A. Smith, P.L.R. Harris, Z. Kubat and R.N. Martins et al., 2002. Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology. J. Neurosci. Res., 70: 514-518.
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  647. Borghi, R., L. Giliberto, A. Assini, A. Delacourte and G. Perry et al., 2002. Increase of cdk5 is related to neurofibrillary pathology in progressive supranuclear palsy. Neurology, 58: 589-592.
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  648. Bishop, G.M., S.R. Robinson, Q. Liu, G. Perry, C.S. Atwood and M.A. Smith, 2002. Iron: A pathological mediator of Alzheimer disease? Dev. Neurosci., 24: 184-187.
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  649. Bishop, G.M., S.R. Robinson, M.A. Smith, G. Perry and C.S. Atwood, 2002. Call for elan to publish Alzheimer's trial details (letter). Nature, 416: 677-677.
  650. Atwood, C.S., R.N. Martins, M.A. Smith and G. Perry, 2002. Senile plaque composition and posttranslational modification of amyloid-β peptide and associated proteins. Peptides, 23: 1343-1350.
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  651. Atwood, C.S., G.M. Bishop, G. Perry and M.A. Smith, 2002. Amyloid-β: A vascular sealant that protects against hemorrhage? J. Neurosci. Res., 70: 356-356.
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  652. Atwood C.S., G.M. Bishop, G. Perry and M.A. Smith, 2002. Commentary: Amyloid-β: A vascular sealant that protects against hemorrhage? J. Neurosci. Res., 70: 356-356.
  653. Aliev, G., M.A. Smith, D. Seyidova, M.L. Neal, J. Shi and M. Loizidou et al., 2002. Increased expression of NOS and ET-1 immunoreactivity in human colorectal metastatic liver tumours is associated with selective depression of constitutive NOS immunoreactivity in vessel endothelium. J. Submicrosc. Cytol. Pathol., 34: 37-50.
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  654. Aliev, G., M.A. Smith, D. Seyidova, M.L. Neal and B.T. Lamb et al., 2002. The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease. Brain Pathol., 12: 21-35.
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  655. Aliev, G., D. Seyidova, M.L. Neal, J. Shi and B.T. Lamb et al., 2002. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Ann. New York Acad. Sci., 977: 45-64.
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  656. Zhu, X., R.J. Castellani, A. Takeda, A. Nunomura, C.S. Atwood, G. Perry and M.A. Smith, 2001. Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease the two hit hypothesis. Mech. Ageing Dev., 123: 39-46.
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  657. Zhu, X., C.A. Rottkamp, A. Hartzler, Z. Sun and A. Takeda et al., 2001. Activation of MKK6, an upstream activator of p38, in Alzheimer's disease. J. Neurochem., 79: 311-318.
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  658. Zhu, X., A.K. Raina, C.A. Rottkamp, G. Aliev, G. Perry, H. Boux and M.A. Smith, 2001. Activation and redistribution of c-Jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J. Neurochem., 76: 435-441.
    Direct Link  |  
  659. Zhou, F., X. Zhu, R.J. Castellani, R. Stimmelmayr, G. Perry, M.A. Smith K.L. and Drew, 2001. Hibernation a model of neuroprotection. Am. J. Pathol., 158: 2145-2151.
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  660. Zhou, F., M.A. Smith, R.J. Castellani, R. Stimmelmayr, G. Perry, K.L. Drew and X. Zhu, 2001. Hibernation, a Model of Neuroprotection. Sci. World J., 10.1100/tsw.2001.132.
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  661. Wong, B.S., T. Liu, D. Paisley, R. Li and T. Pan et al., 2001. Induction of HO-1 and NOS in Doppel-expressing mice devoid of PrP implications for Doppel function. Mol. Cell. Neurosci., 17: 768-775.
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  662. Wong, B.S., T. Liu, R. Li, T. Pan and R.B. Petersen et al., 2001. Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein. J. Neurochem., 76: 565-572.
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  663. Smith, M.A., G. Perry and R. Castellani, 2001. FTD and ADHD: Pathology versus pathophysiology. Neurol. Psychiatr, 9: 137-138.
  664. Sayre, L.M., M.A. Smith and G. Perry, 2001. Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr. Med. Chem., 8: 721-738.
    CrossRef  |  Direct Link  |  
  665. Rottkamp, C.A., A.K. Raina, X. Zhu, E. Gaier and A.I. Bush et al., 2001. Redox-active iron mediates amyloid-β- toxicity. Free Radic. Biol. Med., 30: 447-450.
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  666. Raina, A.K., A. Hochman, X. Zhu , C.A. Rottkamp and A. Nunomura et al., 2001. Abortive apoptosis in Alzheimer's disease. Acta Neuropathol., 101: 305-310.
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  667. Perry, G., X. Zhu and M.A. Smith, 2001. Commentary: Do neurons have a choice in death? Am. J. Pathol., 158: 1-2.
  668. Perry, G., J. Avila, M.G. Espey, D.A. Wink, C.S. Atwood and M.A. Smith, 2001. Biochemistry of neurodegeneration. Science, 291: 595-597.
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  669. Perry, G., B.S. Kumar and M.A. Smith, 2001. Journal of Alzheimer's Disease established as a leading journal. J. Alzheimers Dis., 3: 521-523.
  670. Perry, G., A. Nunomura, S.L. Siedlak, P.L.R. Harris and X. Zhu et al., 2001. Oxidant and antioxidant responses in Alzheimer disease. Recent Res. Dev. Biophys. Biochem., 1: 35-41.
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  671. Perry, G., A. Nunomura, J. Avila, M. Perez and C.A. Rottkamp et al., 2001. Oxidative Damage and Antioxidant Responses in Alzheimer's Disease. In: Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics, Iqbal, K., S.S. Sisodia and B. Winblad (Eds.). John Wiley and Sons, Chichester, UK., pp: 371-378.
  672. Pappolla, M.A., R.A. Omar, Y.J. Chyan and J. Ghiso et al., 2001. Induction of NADPH cytochrome P450 reductase by the Alzheimer amyloid β-protein. Amyloid as a foreign body. J. Neurochem., 78: 121-128.
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  673. Nunomura, A., G. Perry, G. Aliev, K. Hirai and A. Takeda et al., 2001. Oxidative damage is the earliest event in Alzheimer disease. J. Neuropathol. Exp. Neurol., 60: 759-767.
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  674. Lilly, K.L.C., M.A. Smith, G. Perry and L.K. Duffy, 2001. Melatonin reduces interleukin secretion in amyloid-β- stressed mouse brain slices. Chem. Biol. Interact., 134: 101-107.
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  675. Josepha, J.A., G. Perry, B. Shukitt-Hale, N.A. Denisova, A. Martin and M.A. Smith, 2001. A diet at amyloid beta? Neurobiol. Aging, 22: 161-163.
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  676. Josepha, J., B. Shukitt-Hale, N.A. Denisova, A. Martin, G. Perry and M.A. Smith, 2001. Copernicus revisited: Amyloid beta in Alzheimer's disease. Neurobiol. Aging, 22: 131-146.
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  677. Hirai, K., G. Aliev, A. Nunomura, H. Fujioka and R.L. Russell et al., 2001. Mitochondrial abnormalities in Alzheimer's disease. J. Neurosci., 21: 3017-3023.
    Direct Link  |  
  678. Clapp-Lilly, K.L., M.A. Smith, G. Perry, P.L. Harris, X. Zhu and L.K. Duffy, 2001. Melatonin acts as antioxidant and pro-oxidant in an organotypic slice culture model of Alzheimer's disease. Neuroreport, 21: 1277-1280.
    Direct Link  |  
  679. Castellani, R.J., P.L. Harris, L.M. Sayre, J. Fujii and N. Taniguchi et al., 2001. Active glycation in neurofibrillary pathology of Alzheimer disease: Nε-(carboxymethyl) lysine and hexitol-lysine. Free Radic. Biol. Med., 31: 175-180.
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  680. Campbell, A., M.A. Smith, L.M. Sayre, S.C. Bondy and G. Perry, 2001. Mechanisms by which metals promote events connected to neurodegenerative diseases. Brain Res. Bull., 55: 125-132.
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  681. Bierhaus, A., S. Schiekofer, M. Schwaninger, M. Andrassy and P.M. Humpert et al., 2001. Diabetes-associated sustained activation of the transcription factor nuclear factor-κB. Diabetes, 50: 2792-2808.
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  682. Avila, J., J.J. Lucas, F. Lim, M. Perez and F. Hernondez et al., 2001. Phosphorylation, Microtubule Binding and Aggregation of Tau Protein in Alzheimer's Disease. In: Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics, Iqbal, K., S.S. Sisodia and B. Winblad (Eds.). John Wiley and Sons, Chichester, UK., pp: 601-607.
  683. Atwood, C.S., X. Huang, R.D. Moir, M.A. Smith and R.E. Tanzi et al., 2001. Neuroinflammatory Responses in the Alzheimer's Disease Brain Promote the Oxidative Post-Translational Modification of Amyloid Deposits. In: Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics, Iqbal, K., S.S. Sisodia and B. Winblad (Eds.). John Wiley and Sons Ltd., Chichester, UK., pp: 341-361.
  684. Aliev, G., S.K. Samedov, D.Y. Seyidova, A. Mironov and G. Burnstock et al., 2001. The morphological features of the development of atherosclerosis in Watanabe heritable hyperlipidemic rabbits (WHHL) [Russian]. Vita Med. J., 1-2: 11-16.
  685. Aliev, G., M.A. Smith, M. Turmaine, M.L. Neal and T.V. Zimina et al., 2001. Atherosclerotic lesions are associated with increased immunoreactivity for inducible nitric oxide synthase and endothelin-1 in thoracic aortic intimal cells of hyperlipidemic Watanabe rabbits. Exp. Mol. Pathol., 71: 40-54.
  686. Aliev, G., M.A. Smith, G. Perry, S.K.H. Samedov and D. Seyidova et al., 2001. The experimental model of Alzheimer's disease and its science pharmacological treatments. Rep. Acad. Sci. Azerbaijan, 57: 112-118.
  687. Aliev, G., D. Seyidova, M.L. Neal, J. Shi and T. Vigano et al., 2001. The effect of agonists and antagonists on the morphology of non-transformed human smooth muscle cell in vitro. J. Submicrosc. Cytol. Pathol., 33: 141-149.
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  688. Aliciguzel, Y., S.N. Ozdem, S.S. Ozdem, U. Karayalcin, S.L. Siedlak, G. Perry and M.A. Smith, 2001. Erythrocyte plasma and serum antioxidant activities in untreated toxic multinodular goiter patients. Free Radic. Biol. Med., 30: 665-670.
    Direct Link  |  
  689. Aliciguzel, Y., S. Ozdem, A.Y. Demir, F. Unal and D. Kumbul et al., 2001. Effect of the herbicide 4-CPA on human erythrocyte antioxidant enzymes in vitro. Redox Rep., 6: 153-154.
  690. Zhu, X., C.A. Rottkamp, H. Boux, A. Takeda, G. Perry and M.A. Smith, 2000. Activation of p38 kinase links tau phosphorylation oxidative stress and cell cycle-related events in Alzheimer disease. J. Neuropathol. Exp. Neurol., 59: 880-888.
    Direct Link  |  
  691. Takeda, A., M.A. Smith, J. Avila, A. Nunomura and S.L. Siedlak et al., 2000. In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of τ induced by 4-hydroxy-2-nonenal modification. J. Neurochem., 75: 1234-1241.
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  692. Takeda, A., G. Perry, N.G. Abraham, B.E. Dwyer and R.K. Kutty et al., 2000. Overexpression of heme oxygenase in neuronal cells, the possible interaction with Tau. J. Biol. Chem., 275: 5395-5399.
    CrossRef  |  Direct Link  |  
  693. Smith, M.A., J.A. Joseph and G. Perry, 2000. Arson: Tracking the culprit in Alzheimer's disease. Ann. New York Acad. Sci., 924: 35-38.
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  694. Smith, M.A., C.A. Rottkamp, A. Nunomura, A.K. Raina and G. Perry, 2000. Oxidative stress in Alzheimer's disease. Biochim. Biophys. Acta Mol. Basis Dis., 1502: 139-144.
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  695. Smith, M.A., A. Nunomura, X. Zhu, A. Takeda and G. Perry, 2000. Metabolic, metallic and mitotic sources of oxidative stress in Alzheimer disease. Antioxidants Redox Signaling, 2: 413-420.
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  696. Smith, M.A. and G. Perry, 2000. Molecular and Cellular Aspects of Oxidative Damage in Alzheimer's Disease. In: Free Radicals in Brain Pathophysiology, Poli, G., E. Cadenas and L. Packer (Eds.). Marcel Dekker Inc., New York, pp: 313-321.
  697. Smith, M.A. and G. Perry, 2000. Molecular and Cellular Aspects of Oxidative Damage in Alzheimer's Disease. In: Free Radicals in Brain Pathophysiology, Poli, G., E. Cadenas and L. Packer (Eds.). CRC Press, Boca Raton, Florida, ISBN: 9780824703172, pp: 313-321.
  698. Shimohama, S., H. Tanino, N. Kawakami, N. Okamura and H. Kodama et al., 2000. Activation of NADPH oxidase in Alzheimer's disease brains. Biochem. Biophys. Res. Commun., 273: 5-9.
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  699. Shi, J., G. Perry, M.A. Smith and R.P. Friedland, 2000. Vascular abnormalities: The insidious pathogenesis of Alzheimer's disease. Neurobiol. Aging, 21: 357-361.
    CrossRef  |  Direct Link  |  
  700. Sayre, L.M., G. Perry, P.L.R. Harris, Y. Liu, K.A. Schubert and M.A. Smith, 2000. In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: A central role for bound transition metals. J. Neurochem., 74: 270-279.
    CrossRef  |  PubMed  |  Direct Link  |  
  701. Sayre, L.M., G. Perry, C.S. Atwood and M.A. Smith, 2000. The role of metals in neurodegenerative diseases. Cell. Mol. Biol., 46: 731-741.
    Direct Link  |  
  702. Rottkamp, C.A., A. Nunomura, K. Hirai, L.M. Sayre, G. Perry and M.A. Smith, 2000. Will antioxidants fulfill their expectations for the treatment of Alzheimer disease? Mechan. Ageing Dev., 116: 169-179.
  703. Rottkamp, C.A., A. Nunomura, A.K. Raina, L.M. Sayre, G. Perry and M.A. Smith, 2000. Oxidative stress, antioxidants and Alzheimer disease. Alzheimer Dis. Assoc. Disorders, 14: S62-S66.
    Direct Link  |  
  704. Raina, A.K., G. Perry, A. Nunomura, L.M. Sayre and M.A. Smith, 2000. Histochemical and immunocytochemical approaches to the study of oxidative stress. Clin. Chem. Laboratory Med., 38: 93-97.
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  705. Perry, G., M.A. Kaminski, A. Nunomura, A.K. Raina and M.A. Smith, 2000. What oxidative stress tells us about therapeutic targets for Alzheimer's disease. Curr. Opin. CPNS Invest. Drugs, 2: 423-426.
  706. Perry, G., A.K. Raina, A. Nunomura, T. Wataya, L.M. Sayre and M.A. Smith, 2000. How important is oxidative damage? Lessons from Alzheimer's disease. Free Radic. Biol. Med., 28: 831-834.
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  707. Perry, G., A. Nunomura, P.K. Jones, C.A. Rottkamp and X. Zhu et al., 2000. Oxidative imbalance is a major feature of Alzheimer disease. Curr. Biochem. Res., 3: 151-156.
  708. Perry, G., A. Nunomura, K. Hirai, A. Takeda, G. Aliev and M.A. Smith, 2000. Oxidative damage in Alzheimer's disease: The metabolic dimension. Int. J. Dev. Neurosci., 18: 417-421.
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  709. Perry, G., A. Nunomura, A.L. Friedlich, M.V. Boswell and L. Brazdil et al., 2000. Factors Controlling Oxidative Damage in Alzheimer Disease: Metals and Mitochondria. In: Free Radicals in Chemistry, Biology and Medicine, Yoshikawa, T., S. Toyokuni, Y. Yamamoto and Y. Naito (Eds.). OICA International Ltd., London, UK., pp: 417-423.
  710. Perry, G., A. Nunomura, A.K. Raina and M.A. Smith, 2000. Amyloid-β junkies. Lancet, 355: 757-757.
    PubMed  |  
  711. Perry, G., A. Nunomura and M.A. Smith, 2000. Homeostatic control of oxidant balance in Alzheimer disease. Recent Res. Dev. Neurochem., 3: 157-159.
  712. Perry, G., A. Nunomura and M.A. Smith, 2000. Amylose Dans la Maladie d'Alzheimer (French). In: Les Amyloses, Grateau, G., M.D. Benson and M. Delpech (Eds.). Medecine-Sciences Flammarion, Paris, pp: 513-518.
  713. Perry, G., 2000. World alzheimer congress 2000, 9-18 July 2000, Washington DC, USA. Invest. Drugs Weekly Highlights, 32: 51-53.
  714. Perry, G., 2000. Neuromuscular disorders and aging: basic and clinical aspects, 14-15 September 2000, Marseille, France. Invest. Drugs Weekly Highlights, 42: 79-81.
  715. Perry, G., 2000. Metals and the Brain-first international conference, 20-23 september 2000, Padova, Italy. Invest. Drugs Weekly Highlights, 42: 86-88.
  716. Perry, G., 2000. Medicinal chemistry of neurodegenerative diseases--fourth international symposium. 30 January-2 February 2000, Cancun, Mexico. Drugs: Invest. Drugs J., 3: 485-489.
  717. Perry, G., 2000. Medicinal Chemistry of neurodegenerative diseases - fourth international symposium, 30 January-2 February, 2000, Cancun, Mexico. Invest. Drugs Weekly Highlights, 8: 27-32.
  718. Perry, G., 2000. International society for free radical research tenth biennial meeting, 16-20 October 2000, Kyoto, Japan. Invest. Drugs Weekly Highlights, 48: 44-47.
  719. Perry, G., 2000. Experimental Biology 2000 (Part III), 15-18 April 2000, San Diego, CA, USA. Invest. Drugs Weekly Highlights, 19: 41-44.
  720. Perry, G., 2000. American association of neuropathologists-76th annual meeting, 8-11 June 2000, Atlanta, GA, USA. Invest. Drugs Weekly Highlights, 26: 25-26.
  721. Perry, G. and M.A. Smith, 2000. Promises and pitfalls of therapeutics to modify oxidant balance in chronic disease. IDrugs: Invest. Drugs J., 3: 371-372.
    Direct Link  |  
  722. Perez, M., R. Cuadros, M.A. Smith, G. Perry and J. Avila, 2000. Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product 4-hydroxy-2-nonenal. FEBS Lett., 486: 270-274.
    Direct Link  |  
  723. Pappolla, M.A., Y.J. Chyan, M. Sos, G. Perry, M.A. Smith and F. Cruz-Sanchez, 2000. Role of Transgenic Models for the Study of Oxidative Neurotoxicity in Alzheimer's Disease. In: Free Radicals in Brain Pathophysiology, Poli, G., E. Cadenas and L. Packer (Eds.). Marcel Dekker Inc., New York, pp: 359-381.
  724. Odetti, P., S. Garibaldi, R. Norese, G. Angelini and L. Marinelli et al., 2000. Lipoperoxidation is selectively involved in progressive supranuclear palsy. J. Neuropathol. Exp. Neurol., 59: 393-397.
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  725. Nunomura, A., S. Chiba, M.A. Smith and G. Perry, 2000. RNA oxidation and Alzheimer's disease (Japanese). Dementia Japan, 14: 39-45.
  726. Nunomura, A., G. Perry, M.A. Pappolla, R.P. Friedland, K. Hirai, S. Chiba and M.A. Smith, 2000. Neuronal oxidative stress precedes amyloid-β- deposition in Down syndrome. J. Neuropathol. Exp. Neurol., 59: 1011-1017.
  727. Mah, A.L., G. Perry, M.A. Smith and M.J. Monteiro, 2000. Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. J. Cell Biol., 151: 847-862.
    PubMed  |  Direct Link  |  
  728. Kim, H.T., R.L. Russell, A.K. Raina, P.L.R. Harris and S.L. Siedlak et al., 2000. Protein disulfide isomerase in Alzheimer disease. Antioxid. Redox Signal., 2: 485-489.
    CrossRef  |  Direct Link  |  
  729. Friedland, R.P., J. Shi, J.C. Lamanna, M.A. Smith and G. Perry, 2000. Prospects for noninvasive imaging of brain amyloid β in Alzheimer's disease. Ann. New York Acad. Sci., 903: 123-128.
    CrossRef  |  Direct Link  |  
  730. Cuajungco, M.P., L.E. Goldstein, A. Nunomura, M.A. Smith and J.T. Limet al., 2000. Evidence that the β-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Aβ by zinc. J. Biol. Chem., 275: 19439-19442.
    CrossRef  |  PubMed  |  Direct Link  |  
  731. Castellani, R.J., S.L. Siedlak, G. Perry and M.A. Smith, 2000. Sequestration of iron by Lewy bodies in Parkinson's disease. Acta Neuropathologica, 100: 111-114.
    CrossRef  |  Direct Link  |  
  732. Castellani, R.J., P.L.R. Harris, A. Lecroisey, N. Izadi-Pruneyre, C. Wandersman, G. Perry and M.A. Smith, 2000. Evidence for a novel heme-binding protein, HasAh, in Alzheimer disease. Antioxid. Redox Signal., 2: 137-142.
    CrossRef  |  PubMed  |  Direct Link  |  
  733. Castellani, R.J., G. Perry and M.A. Smith, 2000. Oxidative Protein Modifications in Rosenthal Fibers: Implications for Alexander's Disease Pathogenesis. In: Free Radicals in Brain Pathophysiology, Poli, G., E. Cadenas and L. Packer (Eds.). Marcel Dekker Inc., New York, pp: 383-392.
  734. Aliev, G., S.K.H. Samedov, D. Seyidova, J.C. LaManna, M.A. Smith, G. Perry and E.K. Gasimov, 2000. The pathogenesis of cerebrovascular lesions in Alzheimer's disease. Rep. Acad. Sci. Azerbaijan, 56: 236-242.
  735. Aliev, G., J. Shi, G. Perry, R.P. Friedland and J.C. Lamanna, 2000. Decreased constitutive nitric oxide synthase, but increased inducible nitric oxide synthase and endothelin-1 immunoreactivity in aortic endothelial cells of Donryu rats on a cholesterol-enriched diet. Anatom. Rec., 260: 16-25.
    CrossRef  |  Direct Link  |  
  736. Zhang, J., G. Perry, M.A. Smith, D. Robertson, S.J. Olson, D.G. Graham and T.J. Montine, 1999. Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. Am. J. Pathol., 154: 1423-1429.
    CrossRef  |  PubMed  |  Direct Link  |  
  737. Smith, M.A., L.M. Sayre and G. Perry, 1999. Primary Involvement of Oxidative Damage and Redox Imbalance in Alzheimer and Other Neurodegenerative Diseases. In: Redox Regulation of Cell Signaling and Its Clinical Application, Packer, L. and J. Yodoi (Eds.). CRC Press, Boca Raton, Florida, ISBN: 9780824719616, pp: 115-126.
  738. Smith, M.A., K. Hirai, A. Nunomura and G. Perry, 1999. Mitochondrial abnormalities: A primary basis for oxidative damage in Alzheimer's disease. Drug Dev. Res., 46: 26-33.
    CrossRef  |  Direct Link  |  
  739. Smith, M.A., G.J. Petot and G. Perry, 1999. Diet and oxidative stress: A novel synthesis of epidemiological data on Alzheimer's disease. J. Alzheimer's Dis., 1: 203-206.
  740. Shi, J., G. Perry, G. Aliev, M.A. Smith, K.H. Ashe and R.P. Friedland, 1999. Serum amyloid P is not present in amyloid β deposits of a transgenic animal model. Neuroreport, 10: 3229-3232.
    PubMed  |  Direct Link  |  
  741. Sayre, L.M., G. Perry and M.A. Smith, 1999. Redox metals and neu rodegenerative disease. Curr. Opin. Chem. Biol., 3: 220-225.
    CrossRef  |  Direct Link  |  
  742. Russell, R.L., S.L. Siedlak, A.K. Raina, J.M. Bautista, M.A. Smith and G. Perry, 1999. Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease. Arch. Biochem. Biophys., 370: 236-239.
    CrossRef  |  Direct Link  |  
  743. Raina, A.K., D.J. Templeton, J.C. Deak, G. Perry and M.A. Smith, 1999. Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's disease. Redox Rep., 4: 23-27.
    CrossRef  |  PubMed  |  Direct Link  |  
  744. Raina, A.K., A. Takeda, A. Nunomura, G. Perry and M.A. Smith, 1999. Genetic evidence for oxidative stress in Alzheimer's disease. Neuroreport, 10: 1355-1357.
    PubMed  |  Direct Link  |  
  745. Perry, G., K. Hirai, A. Nunomura, A. Raina and M.A. Smith, 1999. Neuronal oxidative damage in Alzheimer disease may be brought about by a fundamental shift in redox balance and oxidative metabolism. Recent Res. Dev. Neurochem., 2: 277-285.
  746. Perry, G., H. Roder, A. Nunomura, A. Takeda and A.L. Friedlich et al., 1999. Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation. Neuroreport, 10: 2411-2415.
    PubMed  |  
  747. Perry, G. and M.A. Smith, 1999. Neurodegeneration Methods and Protocols. In: Methods in Molecular Medicine, Harry, J. and H.A. Tilson (Eds.). Vol. 22, Humana Press, Totowa, New Jersey.
  748. Perry, G. and M.A. Smith, 1999. Alzheimer's Disease. In: Encyclopedia of Neuroscience, Adelman, G. and B.H. Smith (Eds.). 2nd Edn., Elsevier, Amsterdam, New York, USA., ISBN: 9780444816122, pp: 59-61.
  749. Nunomura, A., G. Perry, M.A. Pappolla, R. Wade, K. Hirai, S. Chiba and M.A. Smith, 1999. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J. Neurosci., 19: 1959-1964.
    Direct Link  |  
  750. Nunomura, A., G. Perry, K. Hirai, G. Aliev, A. Takeda, S. Chiba and M.A. Smith, 1999. Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome. Ann. N. Y. Acad. Sci., 893: 362-364.
    CrossRef  |  Direct Link  |  
  751. Nunomura, A., G. Perry, J. Zhang, T.J. Montine, A. Takeda, S. Chiba and M.A. Smith, 1999. RNA oxidation in Alzheimer and Parkinson diseases. J. Anti-Aging Med., 2: 227-230.
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  752. Morgan, T.E., Z. Xie, S. Goldsmith, T. Yoshida and A.S. Lanzrein et al., 1999. The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction. Neuroscience, 89: 687-699.
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  753. Gerst, J.L., L.S. Siedlak, A. Nunomura, R. Castellani, G. Perry and M.A. Smith, 1999. Role of oxidative stress in frontotemporal dementia. Dement. Geriatr. Cogn. Disord., 10: 85-87.
  754. Chen, X., D. Eswaran, M.A. Smith, G. Perry and V.E. Anderson, 1999. Universal isolation of cross-linked peptides: Application to neurofibrillary tangles. Bioconjugate Chem., 10: 112-118.
    CrossRef  |  Direct Link  |  
  755. Castellani, R.J., M.A. Smith, A. Nunomura, P.L.R. Harris and G. Perry, 1999. Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin? Free. Radic. Biol. Med., 26: 1508-1512.
    CrossRef  |  Direct Link  |  
  756. Castellani, R.J., G. Perry, D.S. Brenner and M.A. Smith, 1999. Alexander disease: Alzheimer disease of the developing brain? Alzheimer Dis. Assoc. Disord., 13: 232-235.
    Direct Link  |  
  757. Capellari, S., S.I.A. Zaidi, C.B. Urig, G. Perry, M.A. Smith and R.B. Petersen, 1999. Prion protein glycosylation is sensitive to redox change. J. Biol. Chem., 274: 34846-34850.
    CrossRef  |  Direct Link  |  
  758. Aliev, G., E. Ragazzi, M.A. Smith, A. Mironov and G. Perry, 1999. Morphological features of regeneration of rabbit aortic endothelium after cryoinduced vascular damage. J. Submicrosc. Cytol. Pathol., 31: 495-502.
    PubMed  |  
  759. Velasco, M.E., M.A. Smith, S.L. Siedlak, A. Nunomura and G. Perry, 1998. Striation is the characteristic neuritic abnormality in Alzheimer disease. Brain Res., 813: 329-333.
    CrossRef  |  Direct Link  |  
  760. Smith, M.A., M. Vasak, M. Knipp, R.J. Castellani and G. Perry, 1998. Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease. Free Radic. Biol. Med., 25: 898-902.
    CrossRef  |  Direct Link  |  
  761. Smith, M.A., L.M. Sayre, V.E. Anderson, P.L.R. Harris, M.F. Beal, N. Kowall and G. Perry, 1998. Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine. J. Histochem. Cytochem., 46: 731-735.
    CrossRef  |  PubMed  |  Direct Link  |  
  762. Smith, M.A., K. Wehr, P.L.R. Harris, S.L. Siedlak, J.R. Connor and G. Perry, 1998. Abnormal localization of iron regulatory protein in Alzheimer's disease. Brain Res., 788: 232-236.
    CrossRef  |  Direct Link  |  
  763. Smith, M.A., K. Hirai, K. Hsiao, M.A. Pappolla and P.L.R. Harris et al., 1998. Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress. J. Neurochem., 70: 2212-2215.
    CrossRef  |  PubMed  |  Direct Link  |  
  764. Smith, M.A., G. Perry and L.M. Sayre, 1998. Protein Oxidation and Glycation in Neurodegenerative Diseases. In: Oxidative Stress in Cancer, AIDS and Neurodegenerative Diseases, Montagnier, L., R. Olivier and C. Pasquier (Eds.). Marcel Dekker, New York, pp: 485-496.
  765. Smith, M.A. and G. Perry, 1998. What are the facts and artifacts of the pathogenensis and etiology of Alzheimer disease? J. Chem. Neuroanat., 16: 35-41.
    CrossRef  |  Direct Link  |  
  766. Smith, M.A. and G. Perry, 1998. The Role of Oxidative Stress in the Pathological Sequelae of Alzheimer Disease. In: Free Radicals, Oxidative Stress and Antioxidants: Pathological and Physiological Significance, Ozben, T. (Ed.). Plenum Press, New York, pp: 195-204.
  767. Perry, G., R.J. Castellani, K. Hirai and M.A. Smith, 1998. Reactive oxygen species mediate cellular damage in Alzheimer disease. J. Alzheimer's Dis., 1: 45-55.
    Direct Link  |  
  768. Perry, G., M.A. Smith, C.E. McCann, S.L. Siedlak, P.K. Jones and R.P. Friedland, 1998. Cerebrovascular muscle atrophy is a feature of Alzheimer's disease. Brain Res., 791: 63-66.
    CrossRef  |  Direct Link  |  
  769. Perry, G., A. Nunomura, P. Lucassen, H. Lassmann and M.A. Smith, 1998. Apoptosis and alzheimer's disease. Science, 282: 1268-1269.
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  770. Perry, G., A. Nunomura and M.A. Smith, 1998. A suicide note from Alzheimer disease neurons? Nat. Med., 4: 897-898.
    CrossRef  |  PubMed  |  Direct Link  |  
  771. Perry, G. and M.A. Smith, 1998. The case for vascular abnormalities in Alzheimer's disease. Curr. Res. Alzheimer's Dis., 3: 181-186.
  772. Perry, G. and M.A. Smith, 1998. Oxidative Damage: An Early and Central Event in the Pathogenesis of Alzheimer Disease. In: Progress in HPLC-HPCE 7:Neurochemical Markers of Degenerative Nervous Diseases and Drug Addiction, Qureshi, G.A., H. Parvez, P. Caudy and S. Parvez (Eds.). VSP Press, Amsterdam, pp: 93-110.
  773. Perry, G. and M.A. Smith, 1998. Neuronal Oxidative Stress is a Common Feature of Alzheimer's and Parkinson's Diseases. In: Advances in Behavioral Biology: Progress in Alzheimer's and Parkinson's Diseases, Fisher, A., I. Hanin and M. Yoshida (Eds.). Plenum Press, New York, pp: 77-80.
  774. Perry, G. and M.A. Smith, 1998. Is oxidative damage central to the pathogenesis of Alzheimer disease? Acta Neurol. Belg., 98: 175-179.
  775. Pappolla, M.A., Y.J. Chyan, R.A. Omar, K. Hsiao, G. Perry, M.A. Smith and P. Bozner, 1998. Evidence of oxidative stress and in vivo neurotoxicity of β-amyloid in a transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo. Am. J. Pathol., 152: 871-877.
    Direct Link  |  
  776. Odetti, P., G. Angelini, D. Dapino, D. Zaccheo and S. Garibaldi et al., 1998. Early glycoxidation damage in brains from Down's syndrome. Biochem. Biophys. Res. Commun., 243: 849-851.
    CrossRef  |  Direct Link  |  
  777. Munch, G., R. Schinzel, C. Loske, A. Wong and N. Durany et al., 1998. Alzheimer's disease-synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts. J. Neural Transm., 105: 439-461.
  778. Kitamura, Y., S. Shimohama, W. Kamoshima, T. Ota and Y. Matsuoka et al., 1998. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Brain Res., 780: 260-269.
    CrossRef  |  Direct Link  |  
  779. Hattori, N., K. Kitagawa, T. Higashida, K. Yagyu and S. Shimohama et al., 1998. Cl--ATPase and Na+/K+-ATPase activities in Alzheimer's disease brains. Neurosci Lett., 254: 141-144.
    CrossRef  |  Direct Link  |  
  780. Guevara, J., B. Espinosa, L. Vazquez, J. Luna, E. Zenteno, G. Perry and R. Mena, 1998. Confocal analysis of abnormal posttranslational protein procesing [sic] in Alzheimer's disease. In: Electron Microscopy, Benavides, H.A.C. and J.M. Yacaman (Eds.). Institute of Physics Publishing, Bristol and Philadelphia, Philadelphia, Pennsylvania, pp: 819-820.
  781. Guevara, J., B. Espinosa, E. Zenteno, L. Vazquez, J. Luna, G. Perry and R. Mena, 1998. Altered glycosylation pattern of proteins in Alzheimer disease. J. Neuropathol. Exp. Neurol., 57: 905-914.
    CrossRef  |  Direct Link  |  
  782. DeWitt, D.A., G. Perry, M. Cohen, C. Doller and J. Silver, 1998. Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease. Exp. Neurol., 149: 329-340.
    CrossRef  |  Direct Link  |  
  783. Castellani, R.J., G. Perry, P.L.R. Harris, M.L. Cohen, L.M. Sayre, R.G. Salomon and M.A. Smith, 1998. Advanced lipid peroxidation end-products in Alexander's disease. Brain Res., 787: 15-18.
    CrossRef  |  PubMed  |  Direct Link  |  
  784. Tabaton, M., G. Perry, M. Smith, M. Vitek and G. Angelini et al., 1997. Is amyloid β-protein glycated in Alzheimer's disease. Neuro Rep., 8: 907-909.
    Direct Link  |  
  785. Smith, M.A., R.H. Nagaraj and G. Perry, 1997. Protocol for quantitative analysis of paired helical filament solubilization a method applicable to insoluble amyloids and inclusion bodies. Brain Res. Protocols, 1: 247-252.
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  786. Smith, M.A., P.L.R. Harris, L.M. Sayre, J.S. Beckman and G. Perry, 1997. Widespread peroxynitrite-mediated damage in Alzheimer's disease. J. Neurosci., 17: 2653-2657.
    Direct Link  |  
  787. Smith, M.A., P.L.R. Harris, L.M. Sayre and G. Perry, 1997. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc. Nat. Acad. Sci. USA., 94: 9866-9868.
    Direct Link  |  
  788. Smith, M.A., L.M. Sayre and G. Perry, 1997. Oxidative Damage in Alzheimer's Disease. In: Neurogerontology and Neurogeriatrics 2: Inflammation and Neuroimmunotrophic Activity in Alzheimer's Disease, Cacabelos, R., B. Winblad and P. Eikelenboom (Eds.). Prous Science Publishers, Barcelona, pp: 57-62.
  789. Smith, M.A., L.M. Sayre and G. Perry, 1997. Morphological Aspects of Oxidative Damage in Alzheimer's Disease. In: Mitochondria and Free Radicals in Neurodegenerative Diseases, Beal, M.F., N. Howell and I. Bodis-Wollner (Eds.). Wiley-Liss Inc., New York, pp: 335-342.
  790. Smith, M.A., G.J. Petot and G. Perry, 1997. Commentary: Diet and oxidative stress: A novel synthesis of epidemiological data on Alzheimer's disease. Alzheimer's Dis. Rev., 2: 58-60.
  791. Smith, M.A. and G. Perry, 1997. The pathogenesis of Alzheimer disease: An alternative to the amyloid hypothesis. J. Neuropathol. Exp. Neurol., 56: 217-217.
  792. Smith, M.A. and G. Perry, 1997. Microscopic evaluation of oxidative damage in Alzheimer disease. Microscopy Microanal., 3: 41-42.
  793. Sayre, L.M., M.G. Zagorski, W.K. Surewicz, G.A. Krafft and G. Perry, 1997. Mechanisms of neurotoxicity associated with amyloid β deposition and the role of free radicals in the pathogenesis of Alzheimer's disease: A critical appraisal. Chem. Res. Toxicol., 10: 518-526.
    CrossRef  |  Direct Link  |  
  794. Sayre, L.M., D.A. Zelasko, P.L.R. Harris, G. Perry, R.G. Salomon and M.A. Smith, 1997. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J. Neurochem., 68: 2092-2097.
    Direct Link  |  
  795. Salomon, R.G., G. Subbanagounder, J. O'Neil, K. Kaur and M.A. Smith et al., 1997. Levuglandin E 2-protein adducts in human plasma and vasculature. Chem. Res. Toxicol., 10: 536-545.
    Direct Link  |  
  796. Perry, G., D.A. Zelasko, L.M. Sayre and M.A. Smith, 1997. Oxidative damage to axonal cytoskeletal proteins. Microscopy Microanal., 3: 43-44.
  797. Perry, G. and M.A. Smith, 1997. A central role for oxidative damage in the pathogenesis and therapeutics of Alzheimer's disease. Alzheimer's Res., 2: 319-324.
  798. Castellani, R.J., G. Perry, P.L.R. Harris, V.M. Monnier, M.L. Cohen and M.A. Smith, 1997. Advanced glycation modification of Rosenthal fibers in patients with Alexander disease. Neurosci. Lett., 231: 79-82.
    Direct Link  |  
  799. Xiao, J., G. Perry, J. Troncoso and M.J. Monteiro, 1996. α-Calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease. J. Neuropathol. Exp. Neurol., 55: 954-963.
    CrossRef  |  Direct Link  |  
  800. Smith, M.A., S.L. Siedlak, P.L. Richey, R.H. Nagaraj, A. Elhammer and G. Perry, 1996. Quantitative solubilization and analysis of insoluble paired helical filaments from Alzheimer disease. Brain Res., 717: 99-108.
    CrossRef  |  
  801. Smith, M.A., P.L. Richey, R.N. Kalaria and G. Perry, 1996. Elastase is associated with the neurofibrillary pathology of Alzheimer disease: A putative link between proteolytic imbalance and oxidative stress. Restorative Neurol. Neurosci., 9: 213-217.
    CrossRef  |  Direct Link  |  
  802. Smith, M.A., M. Tabaton and G. Perry, 1996. Early contribution of oxidative glycation in Alzheimer disease. Neurosci. Lett., 217: 210-211.
  803. Smith, M.A., L.M. Sayre, V.M. Monnier and G. Perry, 1996. Oxidative posttranslational modifications in Alzheimer disease. Mol. Chem. Neuropathol., 28: 41-48.
    CrossRef  |  Direct Link  |  
  804. Smith, M.A., L. Sayre and G. Perry, 1996. Is Alzheimer's a disease of oxidative stress? Alzheimer's Dis. Rev., 1: 63-67.
  805. Smith, M.A., G. Perry, P.L. Richey, L.M. Sayre, V.E. Anderson, M.F. Beal and N. Kowall, 1996. Oxidative damage in Alzheimer's. Nature, 382: 120-121.
    CrossRef  |  Direct Link  |  
  806. Smith, M.A., 1996. Diabetes mellitus and Alzheimer's disease: Glycation as a biochemical link. Diabetologia, 39: 247-247.
    CrossRef  |  Direct Link  |  
  807. Smith, M.A. and G. Perry, 1996. Protein Modifications and Interactions in Alzheimer's Disease. In: Alzheimer's Disease: Etiological Mechanisms and Therapeutic Possibilities, Turner, J.D., K. Beyreuther and F. Theuring (Eds.). Springer, Berlin, pp: 169-182.
  808. Smith, M.A. and G. Perry, 1996. Oxidative Stress and Protein Modification in Neurodegenerative Disease. In: Free Radicals in Brain Physiology and Disorders, Packer, L., M. Hiramatsu and T. Yoshikawa (Eds.). Academic Press, San Diego, pp: 287-292.
  809. Smith, M.A. and G. Perry, 1996. Diseases of the aging brain-the role of oxidative stress. Physician's Newslett., 1: 3-4.
  810. Smith, M.A. and G. Perry, 1996. Alzheimer disease: Protein-protein interaction and oxidative stress. Boletin de Estudios Medicos y Biologicos, 44: 5-10.
    PubMed  |  
  811. Savage, M.J., D.S. Howland, S.M. Ali, S. Siedlak and G. Perry et al., 1996. APP Transgenesis: Approaches Towards the Development of Animal Models for Alzheimer's Disease Neuropathology. In: Neurobiology of Alzheimer's Disease, Dawbarn, D. and S. Allen (Eds.). BIOS Scientific Publishers Ltd., Oxford, pp: 149-192.
  812. Praprotnik, D., M.A. Smith, P.L. Richey, H.V. Vinters and G. Perry, 1996. Plasma membrane fragility in dystrophic neurites in senile plaques of Alzheimer's disease an index of oxidative stress. Acta Neuropathol., 91: 226-235.
    CrossRef  |  
  813. P39. Smith, M.A., C.E. Dunbar, E.J. Miller and G. Perry, 1996. Trypsin interaction with the senile plaques of Alzheimer disease is mediated by β-protein precursor. Mol. Chem. Neuropathol., 27: 145-154.
  814. Greenberg, B.D., M.J. Savage, D.S. Howland, S.M. Ali and S.L. Siedlak et al., 1996. APP transgenesis: Approaches toward the development of animal models for Alzheimer disease neuropathology. Neurobiol. Aging, 17: 153-171.
  815. Giaccone, G., B. Pedrotti, A. Migheli, L. Verga and J. Perez et al., 1996. βPP and tau interaction: a possible link between amyloid and neurofibrillary tangles in Alzheimer's disease. Am. J. Pathol., 148: 79-87.
    Direct Link  |  
  816. Castellani R., M.A. Smith, P.J. Richey and G. Petty, 1996. Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease. Brain Res., 737: 195-200.
  817. Ali, S.M., S.L. Siedlak, P.A. Gonzalez-DeWhitt, R.A. Altman and J.M. Glendening et al., 1996. Artifactual strain-specific signs of incipient brain amyloidosis in APP transgenic mice. Neurobiol. Aging, 17: 223-234.
    CrossRef  |  Direct Link  |  
  818. Yan, S.D., S.F. Yan, X. Chen, J. Fu and M. Chen et al., 1995. Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide. Nat. Med., 1: 693-699.
  819. Tabaton, M., M. Rolleri, P. Masturzo, S. Cammarata and G. Angelini et al., 1995. Apolipoprotein E element 4 allele frequency is not increased in progressive supranuclear palsy. Neurology, 45: 1764-1765.
    CrossRef  |  Direct Link  |  
  820. Smith, M.A., V.M. Monnier, L.M. Sayre and G. Perry, 1995. Amyloidosis, advanced glycation end products and Alzheimer disease. Neuroreport, 6: 1595-1595.
    Direct Link  |  
  821. Smith, M.A., S.L. Siedlak, P.L. Richey, P. Mulvihill and J. Ghiso et al., 1995. Tau protein directly interacts with the amyloid β-protein precursor: implications for Alzheimer's disease. Nat. Med., 1: 365-369.
  822. Smith, M.A., P.L. Richey, R.K. Kutty, B. Wiggert and G. Perry, 1995. Ultrastructural localization of heme oxygenase-1 to the neurofibrillary pathology of Alzheimer disease. Mol. Chem. Neuropathol., 24: 227-230.
    CrossRef  |  Direct Link  |  
  823. Smith, M.A., M.R.-Nawrot, P.L. Richey, D. Praprotnik and P. Mulvihill et al., 1995. Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease. J. Neurochem., 64: 2660-2666.
    Direct Link  |  
  824. Smith, M.A., L.M. Sayre, V.M. Monnier and G. Perry, 1995. Radical AGEing in Alzheimer's disease. Trends Neurosci., 18: 172-176.
    CrossRef  |  Direct Link  |  
  825. Smith, M.A., L.M. Sayre, M.P. Vitek, V.M. Monnier and G. Perry, 1995. Early AGEing and Alzheimer's. Nature, 374: 316-316.
    CrossRef  |  Direct Link  |  
  826. Smith, M.A., D.A. DeWitt, D. Praprotnik and G. Perry, 1995. Senile plaques and neurofibrillary tangles: The concurrent lesions of Alzheimer's disease. Neurobiol Aging, 16: 343-344.
    Direct Link  |  
  827. Smith, M.A. and G. Perry, 1995. Free radical damage, iron and Alzheimer's disease. J. Neurol. Sci., 134: 92-94.
    CrossRef  |  Direct Link  |  
  828. Shimohama, S., S. Fujimoto, M. Chachin, T. Taniguchi, G. Perry, P.J. Whitehouse and J. Kimura, 1995. Alterations of low molecular weight acid phosphatase protein level in Alzheimer's disease. Brain Res., 699: 125-129.
    CrossRef  |  Direct Link  |  
  829. Shimohama, S., S. Fujimoto, H. Matsushima, T. Takenawa and T. Taniguchi et al., 1995. Alteration of phospholipase C‐δ protein level and specific activity in alzheimer's disease. J. Neurochem., 64: 2629-2634.
    CrossRef  |  Direct Link  |  
  830. Shimohama, S., G. Perry, P. Richey, D. Praprotnik and T. Takenawa et al., 1995. Characterization of the association of phospholipase C-δ with Alzheimer neurofibrillary tangles. Brain Res., 669: 217-224.
    CrossRef  |  Direct Link  |  
  831. Rifenburg, R.P. and G. Perry, 1995. Dystrophic neurites define diffuse as well as core-containing senile plaques in Alzheimer's disease. Neurodegeneration, 4: 235-237.
    PubMed  |  
  832. Richey, P.L., S.L. Siedlak, M.A. Smith and G. Perry, 1995. Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer disease implications for disease pathogenesis. Biochem. Biophys. Res. Commun., 208: 657-663.
    Direct Link  |  
  833. Premkumar, D.R.D., M.A. Smith, P.L. Richey, R.B. Petersen and R. Castellani et al., 1995. Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease. J. Neurochem., 65: 1399-1402.
    Direct Link  |  
  834. Kindy, M.S., A.R. King, G. Perry, M.C. De Beer and F.C. De Beer, 1995. Association of apolipoprotein E with murine amyloid A protein amyloid. Lab. Invest. J. Tech. Methods Pathol., 73: 469-475.
    Direct Link  |  
  835. DeWitt, D.A., D.R. Canning, J. Silver and G. Perry, 1995. Glial Cell Extracellular Matrix in Alzheimer's Disease. In: Non-Neuronal Cells in Alzheimer's Disease, Zatta, P. and M. Nicolini (Eds.). World Scientific Publishing Co., London, pp: 158-170.
  836. Cras, P., M.A. Smith, P.L. Richey, S.L. Siedlak, P. Mulvihill and G. Perry, 1995. Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease. Acta Neuropathol., 89: 291-295.
    CrossRef  |  
  837. Castellani, R., M.A. Smith, P.L. Richey, R. Kalaria, P. Gambetti and G. Perry, 1995. Evidence for oxidative stress in Pick disease and corticobasal degeneration. Brain Res., 696: 268-271.
    CrossRef  |  
  838. Yan, S.D., X. Chen, A.M. Schmidt J. Brett and G. Godman et al., 1994. Glycated tau protein in Alzheimer disease: A mechanism for induction of oxidant stress. Proc. Natl. Acad. Sci. USA., 91: 7787-7791.
    Direct Link  |  
  839. Smith, M.A., S. Taneda, P.L. Richey, S. Miyata and S.D. Yan et al., 1994. Advanced Maillard reaction end products are associated with Alzheimer disease pathology. Proc. Natl. Acad. Sci. USA., 91: 5710-5714.
    Direct Link  |  
  840. Smith, M.A., R.K. Kutty, P.L. Richey, S.D. Yan and D. Stern et al., 1994. Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease. Am. J. Pathol., 145: 42-47.
    Direct Link  |  
  841. Smith, M.A., P.L. Richey, S. Taneda, R.K. Kutty, L.M. Sayre, V.M. Monnier and G. Perry, 1994. Advanced Maillard Reaction End Products, Free Radicals and Protein Oxidation in Alzheimer's Disease. In: The Neurobiology of NO• and OH, Chuieh, C.C., D.L. Gilbert and C.A. Colton (Eds.). Acad Science, USA., pp: 447-454.
  842. Smith, M.A. and G. Perry, 1994. Is a Lewy Body Always a Lewy Body? In: Dementia in Parkinson's Disease, Korczyn, A.D. (Ed.). Monduzzi Editore, Bologna, Italy, pp: 187-193.
  843. Smith, M.A. and G. Perry, 1994. Alzheimer disease: An imbalance of proteolytic regulation? Med. Hypotheses, 42: 277-279.
    CrossRef  |  Direct Link  |  
  844. Gambetti, P. and G. Perry, 1994. Alzheimer's disease and prion proteins: A meeting made in muscle. Am. J. Pathol., 145: 1261-1264.
    Direct Link  |  
  845. Dewitt, D.A., P.L. Richey, D. Praprotnik, J. Silver and G. Perry, 1994. Chondroitin sulfate proteoglycans are a common component of neuronal inclusions and astrocytic reaction in neurodegenerative diseases. Brain Res., 656: 205-209.
    CrossRef  |  Direct Link  |  
  846. Villanova, M., U. Lubke, M. Vandermeeren, M. Mercken and G.C. Guazzi et al., 1993. Rimmed vacuoles in oculopharyngeal muscular dystrophy contain amyloid precursor protein. In: Advances in the Biosciences 87: Alzheimer's Disease and Related Disorders, Nicolini, M., P.F. Zatta and B. Corain (Eds.). Pergamon Press, Oxford, pp: 157-158.
  847. Villanova, M., M. Kawai, U. Lubke, S.J. Oh and G. Perry et al., 1993. Rimmed vacuoles of inclusion body myositis and oculopharyngeal muscular dystrophy contain amyloid precursor protein and lysosomal markers. Brain Res., 603: 343-347.
    CrossRef  |  Direct Link  |  
  848. Smith, M.A., R.N. Kalaria and G. Perry, 1993. Proteolytic Anomalies in Alzheimer Disease. In: Amyloid and Amyloidosis, Kisilevsky, R., M. Benson, B. Frangione, J. Gauldie, T.J. Muckle and I.D. Young (Eds.). Parthenon Press, New York, pp: 335-337.
  849. Smith, M.A., R.N. Kalaria and G. Perry, 1993. α1-Trypsin immunoreactivity in Alzheimer disease. Biochem. Biophys. Res. Commun., 193: 579-584.
    CrossRef  |  
  850. Smith, M.A., P.L. Richey, C.A. Miller, M.T. Nawrot and G. Perry, 1993. Carbonyl-Crosslinking in Alzheimer Disease: Pathogenic Considerations. In: Amyloid and Amyloidosis, Kisilevsky, R., M. Benson, B. Frangione, J. Gauldie, T.J. Muckle and I.D. Young (Eds.). Parthenon Press, New York, pp: 371-373.
  851. Sisodia, S.S., E.H. Koo, P.N. Hoffman, G. Perry and D.L. Price, 1993. Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. J. Neurosci., 13: 3136-3142.
    Direct Link  |  
  852. Shimohama, S., S. Fujimoto, N. Tresser, P. Richey and G. Perry et al., 1993. Aberrant phosphoinositide metabolism in Alzheimer's diseasea. Ann. New York Acad. Sci., 695: 46-49.
    CrossRef  |  Direct Link  |  
  853. Shimohama, S., G. Perry, P. Richey, T. Takenawa and P.J. Whitehouse et al., 1993. Abnormal accumulation of phospholipase C-δ in filamentous inclusions of human neurodegenerative diseases. Neurosci. Lett., 162: 183-186.
    CrossRef  |  Direct Link  |  
  854. Perry, G., P.L. Richey, S.L. Siedlak, M.A. Smith and P. Mulvihill et al., 1993. Immunocytochemical evidence that the β-protein precursor is an integral component of neurofibrillary tangles of Alzheimer's disease. Am. J. Pathol., 143: 1586-1593.
    Direct Link  |  
  855. Perry, G., M.A. Smith, P. Mulvihill, S.L. Siedlak, P.L. Richey, D.A. DeWitt and R.N. Kalaria, 1993. Alzheimer Disease: Concurrent Amyloidoses. In: Amyloid and Amyloidosis, Kisilevsky, R., M. Benson, B. Frangione, J. Gauldie, T.J. Muckle and I.D. Young (Eds.). Parthenon Press, New York, pp: 374-376.
  856. Perry, G., M. Kawai, R.N. Kalaria, M. Tabaton and P. Cras, 1993. Origin of Neuritic Plaques in Alzheimer Disease. In: Advances in the Biosciences 87: Alzheimer's Disease and Related Disorders, Nicolini, M. and B.Z. Corain (Eds.). Pergamon Press, Oxford, pp: 153-154.
  857. Perry, G., 1993. Neuritic plaques in Alzheimer disease originate from neurofibrillary tangles. Med. Hypotheses, 40: 257-258.
    CrossRef  |  Direct Link  |  
  858. Perry, G. and M.A. Smith, 1993. Senile plaques and neurofibrillary tangles: What role do they play in Alzheimer's disease. Clin. Neurosci., 1: 199-203.
  859. Kawai, M., R.N. Kalaria, P. Cras, S.L. Siedlak and M.E. Velasco et al., 1993. Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease. Brain Res., 623: 142-146.
    CrossRef  |  Direct Link  |  
  860. Kalaria, R.N., T. Golde, S.N. Kroon and G. Perry, 1993. Serine protease inhibitor antithrombin III and its messenger RNA in the pathogenesis of Alzheimer's disease. Am. J. Pathol., 143: 886-893.
    Direct Link  |  
  861. Kalaria, R.N., S.U. Bhatti, W.D. Lust and G. Perry, 1993. The amyloid precursor protein in ischemic brain injury and chronic hypoperfusiona. Ann. New York Acad. Sci., 695: 190-193.
    CrossRef  |  Direct Link  |  
  862. Kalaria, R.N., S.U. Bhatti, E.A. Palatinsky, D.H. Pennington and E.R. Shelton et al., 1993. Accumulation of the β amyloid precursor protein at sites of ischemic injury in rat brain. Neuroreport, 4: 211-214.
    PubMed  |  Direct Link  |  
  863. Kalaria, R.N., S.N. Kroon and G. Perry, 1993. Serum Proteins and the Blood-Brain Barrier in the Pathogenesis Of Alzheimer's Disease. In: Advances in the Biosciences 87: Alzheimer's Disease and Related Disorders., Nicolini, M., P.F. Zatta and B. Corain (Eds.). Pergamon Press, Oxford, pp: 281-282.
  864. Kalaria, R.N. and G. Perry, 1993. Amyloid P component and other acute-phase proteins associated with cerebellar aβ-deposits in Alzheimer's disease. Brain Res., 631: 151-155.
    CrossRef  |  Direct Link  |  
  865. Holash, J.A., S.I. Harik, G. Perry and P.A. Stewart, 1993. Barrier properties of testis microvessels. Proc. Natl. Acad. Sci.,. 90: 11069-11073.
    Direct Link  |  
  866. Harik, S.I., A.K. Hall, P. Richey, L. Andersson, P. Lundahl and G. Perry, 1993. Ontogeny of the erythroid/HepG2-type glucose transporter (GLUT-1) in the rat nervous system. Dev. Brain Res., 72: 41-49.
    CrossRef  |  Direct Link  |  
  867. Greenberg, B.D., S.M. Ali, D. Howland, P.A. Gonzalez-DeWhitt and R.A. Altman et al., 1993. Transgenic Mouse Studies of Alzheimer Amyloid Precursor. In: Amyloid and Amyloidosis, Kisilevsky, R., M. Benson, B. Frangione, J. Gauldie, T.J. Muckle and I.D. Young (Eds.). Parthenon Press, New York, pp: 328-331.
  868. Dewitt, D.A., J. Silver, D.R. Canning and G. Perry, 1993. Chondroitin sulfate proteoglycans are associated with the lesions of Alzheimer's disease. Exp. Neurol., 121: 149-152.
    Direct Link  |  
  869. DeWitt, D.A., J. Silver, D.R. Canning and G. Perry, 1993. Chondroitin Sulfate Proteoglycan and the Regenerative Failure Model of Alzheimer's Disease. In: Amyloid and Amyloidosis, Kisilevsky, R., M. Benson, B. Frangione, J. Gauldie, T.J. Muckle and I.D. Young (Eds.). Parthenon Press, New York, pp: 347-349.
  870. Cisse, S., G. Perry, G. Lacoste-Royal, T. Cabana and D. Gauvreau, 1993. Immunochemical identification of ubiquitin and heat-shock proteins in corpora amylacea from normal aged and Alzheimer's disease brains. Acta Neuropathol., 85: 233-240.
    CrossRef  |  Direct Link  |  
  871. Canning, D.R., R.J. McKeon, D.A. DeWitt, G. Perry, J.R. Wujek, R.C.A. Frederickson and J. Silver, 1993. β-Amyloid of Alzheimer's disease induces reactive gliosis that inhibits axonal outgrowth. Exp. Neurol., 124: 289-298.
    CrossRef  |  Direct Link  |  
  872. Tabaton, M., S. Cammarata, T. Mandybur, P. Richey, M. Kawai, G. Perry and P. Gambetti, 1992. Senile plaques in cerebral amyloid angiopathy show accumulation of amyloid precursor protein without cytoskeletal abnormalities. Brain Res., 593: 299-303.
    CrossRef  |  Direct Link  |  
  873. Perry, G., P. Richey, S.L. Siedlak, P. Galloway, M. Kawai and P. Cras, 1992. Basic fibroblast growth factor binds to filamentous inclusions of neurodegenerative diseases. Brain Res., 579: 350-352.
    CrossRef  |  Direct Link  |  
  874. Perry, G., P. Cras, S.L. Siedlak, M. Tabaton and M. Kawai, 1992. Βeta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease. Am. J. Pathol., 140: 283-290.
    Direct Link  |  
  875. Perry, G., 1992. Alzheimer's Disease. In: Neuroscience Year, Smith, B. and G. Adelman (Eds.). Birkhauser, Boston, pp: 5-8.
  876. Kawai, M., P. Cras, P. Richey, M. Tabaton and D.E. Lowery et al., 1992. Subcellular localization of amyloid precursor protein in senile plaques of Alzheimer's disease. Am. J. Pathol., 140: 947-958.
    Direct Link  |  
  877. Kawai, M., P. Cras and G. Perry, 1992. Serial reconstruction of β-protein amyloid plaques: Relationship to microvessels and size distribution. Brain Res., 592: 278-282.
    CrossRef  |  Direct Link  |  
  878. Kalaria, R.N., S.N. Kroon, I. Grahovac and G. Perry, 1992. Acetylcholinesterase and its association with heparan sulphate proteoglycans in cortical amyloid deposits of Alzheimer's disease. Neuroscience, 51: 177-184.
    CrossRef  |  Direct Link  |  
  879. Hirose, S., R.P. Mohney, S.C. Mutka, L. Ravi and D.R. Singleton et al., 1992. Derivation and characterization of glycoinositol-phospholipid anchor-defective human K562 cell clones. J. Biol. Chem., 267: 5272-5278.
    Direct Link  |  
  880. Gollin, P.A., R.N. Kalaria, P. Eikelenboom, A. Rozemuller and G. Perry, 1992. [alpha] 1-Antitrypsin and [alpha] 1-antichymotrypsin are in the lesions of Alzheimer's disease. Neuroreport, 3: 201-203.
    Direct Link  |  
  881. Galloway, P.G., P. Mulvihill and G. Perry, 1992. Filaments of Lewy bodies contain insoluble cytoskeletal elements. Am. J. Pathol., 140: 809-822.
    Direct Link  |  
  882. Candy, J.M., F.K. McArthur, A.E. Oakley, G.A. Taylor and C.H. Chen et al., 1992. Aluminium accumulation in relation to senile plaque and neurofibrillary tangle formation in the brains of patients with renal failure. J. Neurol. Sci., 107: 210-218.
    CrossRef  |  Direct Link  |  
  883. Aikawa, M., A. Brown, C.D. Smith, T. Tegoshi and R.J. Howard et al., 1992. A primate model for human cerebral malaria: Plasmodium coatneyi-infected rhesus monkeys. Am. J. Trop. Med. Hygiene, 46: 391-397.
    Direct Link  |  
  884. Weghe, J.V., P. Cras, M. Kawai, S.L. Siedlak, M. Tabaton, B. Greenberg and G. Perry, 1991. Dystrophic neurites infiltrate extracellular neurofibrillary tangles in Alzheimer disease. Brain Res., 560: 303-305.
    CrossRef  |  Direct Link  |  
  885. Tabaton, M., S. Cammarata, G.L. Mancardi, G. Cordone, G. Perry and C. Loeb, 1991. Abnormal tau‐reactive filaments in olfactory mucosa in biopsy specimens of patients with probable Alzheimer's disease. Neurology, 41: 391-391.
    CrossRef  |  Direct Link  |  
  886. Tabaton, M., S. Cammarata, G. Mancardi, V. Manetto, L. Autilio-Gambetti, G. Perry and P. Gambetti, 1991. Ultrastructural localization of beta-amyloid, tau and ubiquitin epitopes in extracellular neurofibrillary tangles. Proc. Nat. Acad. Sci., 88: 2098-2102.
    CrossRef  |  Direct Link  |  
  887. Siedlak, S.L., P. Cras, M. Kawai, P. Richey and G. Perry, 1991. Basic fibroblast growth factor binding is a marker for extracellular neurofibrillary tangles in Alzheimer disease. J. Histochem Cytochem, 39: 899-904.
  888. Perry, G., S.L. Siedlak, P. Richey, M. Kawai and P. Cras et al., 1991. Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease. J. Neurosci., 11: 3679-3683.
    Direct Link  |  
  889. Perry, G., P. Cras, M. Kawai, P. Mulvihill and M. Tabaton, 1991. Transformation of neurofibrillary tangles in the extracellular space. Bull. Clin. Neurosci., 56: 107-119.
  890. Perry, G., M. Kawai, M. Tabaton, M. Onorato and P. Mulvihill et al., 1991. Neuropil threads of Alzheimer's disease show a marked alteration of the normal cytoskeleton. J. Neurosci., 11: 1748-1755.
    Direct Link  |  
  891. Kalaria, R.N., P.G. Galloway and G. Perry, 1991. Widespread serum amyloid P immunoreactivity in cortical amyloid deposits and the neurofibrillary pathology of Alzheimer's disease and other degenerative disorders. Neuropathol. Applied Neurobiol., 17: 189-201.
    CrossRef  |  Direct Link  |  
  892. Gheuens, J., P. Cras, G. Perry, J. Boons and C. Ceuterick-de Groote et al., 1991. Demonstration of a novel neurofilament associated antigen with the neurofibrillary pathology of Alzheimer and related diseases. Brain Res., 558: 43-52.
    CrossRef  |  Direct Link  |  
  893. Galloway, P.G. and G. Perry, 1991. Tropomyosin distinguishes Lewy bodies of Parkinson disease from other neurofibrillary pathology. Brain Res., 541: 347-349.
    CrossRef  |  
  894. Cras, P., M. Kawai, S. Siedlak and G. Perry, 1991. Microglia are associated with the extracellular neurofibrillary tangles of Alzheimer disease. Brain Res., 558: 312-314.
    CrossRef  |  Direct Link  |  
  895. Cras, P., M. Kawai, D. Lowery, P. Gonzalez-Dewhitt, B. Greenberg and G. Perry, 1991. Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. Proc. Nat. Acad. Sci., 88: 7552-7556.
    Direct Link  |  
  896. Cras, P. and G. Perry, 1991. Dementia with argyrophilic grains. Ann. Neurol., 30: 853-853.
    CrossRef  |  Direct Link  |  
  897. Murphy, G.M., L.F. Eng, W.G. Ellis, G. Perry, L.C. Meissner and J.R. Tinklenberg, 1990. Antigenic profile of plaques and neurofibrillary tangles in the amygdala in Down's syndrome: A comparison with Alzheimer's disease. Brain Res., 537: 102-108.
    CrossRef  |  Direct Link  |  
  898. Kawai, M., R.N. Kalaria, S.I. Harik and G. Perry, 1990. The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease. Am. J. Pathol., 137: 1435-1446.
    Direct Link  |  
  899. Kawahara, H., M. Cadrin, G. Perry, L. Autilio-Gambetti and S.H.H. Swierenga et al., 1990. Role of cytokeratin intermediate filaments in transhepatic transport and canalicular secretion. Hepatology, 11: 435-448.
    CrossRef  |  Direct Link  |  
  900. Kasper, M., G. Perry and P. Stosiek, 1990. Cytokeratin expression in human spinal meninges and ependymal cells. J. fur Hirnforschung, 32: 19-25.
    Direct Link  |  
  901. Harik, S.I., R.N. Kalaria, P.M. Whitney, L. Andersson, P. Lundahl, S.R. Ledbetter and G. Perry, 1990. Glucose transporters are abundant in cells with occluding junctions at the blood-eye barriers. Proc. Nat. Acad. Sci., 87: 4261-4264.
    CrossRef  |  Direct Link  |  
  902. Harik, S.I., R.N. Kalaria, L. Andersson, P. Lundahl and G. Perry, 1990. Immunocytochemical localization of the erythroid glucose transporter: Abundance in tissues with barrier functions. J. Neurosci., 10: 3862-3872.
    Direct Link  |  
  903. Golde, T.E., M.R. Palmert, S. Estus, M. Usiak and S.L. Siedlak et al., 1990. The β Amyloid Protein Precursor: Analysis of mRNAs in AD and Control Brains and of Soluble Derivatives in Human Cerebrospinal Fluid. In: International Congress Series 884: Molecular Biology and Genetics of Alzheimer's Disease, Miyatake, T., D.J. Selkoe and Y. Ihara (Eds.). Elsevier Publishing, Amsterdam, pp: 137-147.
  904. Gambetti, P., M. Tabaton, S. Cammarata, A. Morandi and B. Schaetzle et al., 1990. Neurofibrillary Tangles, Neuropil Threads and Neuritic Plaques in Alzheimer Disease: Are these Lesions Interrelated? In: International Congress Series 884: Molecular Biology and Genetics of Alzheimer's Disease, Miyatake, T., D.J. Selkoe and Y. Ihara (Eds.). Elsevier Publishing, Amsterdam, pp: 57-66.
  905. Galloway, P.G., P. Mulvihill, S. Siedlak, M. Mijares and M. Kawai et al., 1990. Immunochemical demonstration of tropomyosin in the neurofibrillary pathology of Alzheimer's disease. Am. J. Pathol., 137: 291-300.
    Direct Link  |  
  906. Galloway, P.G., M.J. Likavec and G. Perry, 1990. Tropomyosin isoform expression in normal and neoplastic astrocytes. Lab. Invest., 62: 163-170.
    PubMed  |  
  907. Galloway, P.G., M.J. Likavec and G. Perry, 1990. Immunohistochemical recognition of ethylnitrosourea induced rat brain microtumors by anti-Leu 7 monoclonal antibody. Cancer Lett., 49: 243-248.
    CrossRef  |  Direct Link  |  
  908. Cras, P., M. Kawai, S. Siedlak, P. Mulvihill and P. Gambetti et al., 1990. Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease. Am. J. Pathol., 137: 241-246.
  909. Whitehouse, P.J., P. Gambetti, S.I. Harik, R.N. Kalaria and G. Perry et al., 1989. Neurochemistry of Dementia: Establishing the Links. In: Progress in Clinical and Biological Research 317: Alzheimer's Disease and Related Disorders, Iqbal, K., H.M. Wisniewski, B. Winblad (Eds.). Alan R. Liss Inc., New York, pp: 131-142.
  910. Tabaton, M., T.I. Mandybur, G. Perry, M. Onorato, L. Autilio-Gambetti and P. Gambetti, 1989. The widespread alteration of neurites in Alzheimer's disease may be unrelated to amyloid deposition. Ann. Neurol., 26: 771-778.
    CrossRef  |  Direct Link  |  
  911. Tabaton, M., S. Cammarata, V. Manetto, G. Perry and G. Mancardi, 1989. Tau-reactive neurofibrillary tangles in cerebellar cortex from patients with Alzheimer's disease. Neurosci. Lett., 103: 259-262.
    CrossRef  |  Direct Link  |  
  912. Perry, G., S. Siedlak, P. Mulvihill, M. Kancherla and M. Mijares et al., 1989. Immunolocalization of the Amyloid Precursor Protein within the Senile Plaque. In: Progress in Clinical and Biological Research 317: Alzheimer's Disease and Related Disorders, Iqbal, K., H.M. Wisniewski and B. Winblad (Eds.). Alan R. Liss Inc., New York, pp: 1021-1025.
  913. Perry, G., P. Mulvihill, V.A. Fried, H.T. Smith, I. Grundke-Iqbal and K. Iqbal, 1989. Immunochemical properties of ubiquitin conjugates in the paired helical filaments of Alzheimer disease. J. Neurochem., 52: 1523-1528.
    CrossRef  |  Direct Link  |  
  914. Palmert, M.R., S.L. Siedlak, M.B. Podlisny, B. Greenberg and E.R. Shelton et al., 1989. Soluble derivatives of the β amyloid protein precursor of Alzheimer's disease are labeled by antisera to the β amyloid protein. Biochem. Biophys. Res. Commun., 165: 182-188.
    CrossRef  |  Direct Link  |  
  915. Onorato, M., P. Mulvihill, J. Connolly, P. Galloway, P. Whitehouse and G. Perry, 1989. Alteration of Neuritic Cytoarchitecture in Alzheimer Disease. In: Progress in Clinical and Biological Research 317: Alzheimer's Disease and Related Disorders, Iqbal, K., H.M. Wisniewski, B. Winblad (Eds)., Alan R. Liss Inc., New York, pp: 781-789.
  916. Mulvihill, P. and G. Perry, 1989. Immunoaffinity demonstration that paired helical filaments of Alzheimer disease share epitopes with neurofilaments, MAP2 and tau. Brain Res., 484: 150-156.
    CrossRef  |  Direct Link  |  
  917. Manetto, V., F.W. Abdul-Karim, G. Perry, M. Tabaton, L. Autilio-Gambetti and P. Gambetti, 1989. Selective presence of ubiquitin in intracellular inclusions. Am. J. Pathol., 134: 505-513.
    Direct Link  |  
  918. Lew, E.O., B. Rozdilsky, D.G. Munoz and G. Perry, 1989. A new type of neuronal cytoplasmic inclusion: Histological, ultrastructural and immunocytochemical studies. Acta Neuropathol., 77: 599-604.
    CrossRef  |  Direct Link  |  
  919. Kasper, M., H.J. Terpe and G. Perry, 1989. Age-dependent pattern of intermediate filament protein expression in the human pineal gland. J. fur Hirnforschung, 31: 215-221.
    Direct Link  |  
  920. Galloway, P.G., C. Bergeron and G. Perry, 1989. The presence of tau distinguishes Lewy bodies of diffuse Lewy body disease from those of idiopathic Parkinson disease. Neurosci. Lett., 100: 6-10.
    CrossRef  |  Direct Link  |  
  921. Autilio-Gambetti, L., A. Morandi, D.M. Kovacs, M. Tabaton and B. Schaetzle et al., 1989. Amyloid Precursor Protein in Cell Cultures: A 130 kDa Polypetide. In: Progress in Clinical and Biological Research 317: Alzheimer's Disease and Related Disorders, Iqbal, K., H.M. Wisniewski, B. Winblad (Eds.). Alan R. Liss Inc., New York, pp: 985-990.
  922. Tabatonm, M., P.J. Whitehouse, G. Perry, P. Davies, L. Autilio-Gambetti and P. Gambetti, 1988. Alz 50 recognizes abnormal filaments in Alzheimer's disease and progressive supranuclear palsy. Ann. Neurol., 24: 407-413.
    CrossRef  |  Direct Link  |  
  923. Tabaton, M., G. Perry, L. Autilio-Gambetti, V. Manetto and P. Gambetti, 1988. Influence of neuronal location on antigenic properties of neurofibrillary tangles. Ann. Neurol., 23: 604-610.
    CrossRef  |  Direct Link  |  
  924. Perry, G., S. Lipphardt, P. Mulvihill, M. Kancherla and M. Mijares et al., 1988. Amyloid precursor protein in senile plaques of Alzheimer disease. Lancet, 332: 746-746.
  925. Perry, G. and C. Lambert, 1988. Arachidonic acid metabolism in Ascidia ceratodes eggs: Role of lipid peroxidation. Comp. Biochem. Physiol. Part B: Comp. Biochem., 90: 785-789.
    CrossRef  |  Direct Link  |  
  926. Ohta, M., N. Marceau, G. Perry, V. Manetto and P. Gambetti et al., 1988. Ubiquitin is present on the cytokeratin intermediate filaments and Mallory bodies of hepatocytes. Lab. Invest., 59: 848-856.
    PubMed  |  
  927. Matsumoto, Y., G. Perry, R.J.C. Levine, R. Blanton, A.A.F. Mahmoud and M. Aikawa, 1988. Paramyosin and actin in schistosomal teguments. Nature, 333: 76-78.
    CrossRef  |  Direct Link  |  
  928. Manetto, V., N.H. Sternberger, G. Perry, L.A. Sternberger and P. Gambetti, 1988. Phosphorylation of neurofilaments is altered in amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol., 47: 642-653.
    CrossRef  |  Direct Link  |  
  929. Manetto, V., G. Perry, M. Tabaton, P. Mulvihill and V.A. Fried et al., 1988. Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases. Proc. Natl. Acad. Sci. USA., 85: 4501-4505.
    Direct Link  |  
  930. Kalaria, R.N., S.A. Gravina, J.W. Schmidley, G. Perry and S.I. Harik, 1988. The glucose transporter of the human brain and blood‐brain barrier. Ann. Neurol., 24: 757-764.
    CrossRef  |  Direct Link  |  
  931. Gambetti, P., V. Manetto, M. Tabaton, P. Mulvihill and V.A. Fried et al., 1988. A New Protein in Alzheimer and Other Neurodegenerative Diseases Ubiquitin. In: Fidia Research Series15: New Trends in Aging Research, New Trends in Aging Research. Pepeu, G., B. Tomlinson and C.M. Wischik (Eds.). Liviana Press, Padova, pp: 153-164.
  932. Galloway, P.G., I. Grundke-Iqbal, K. Iqbal and G. Perry, 1988. Lewy bodies contain epitopes both shared and distinct from Alzheimer neurofibrillary tangles. J. Neuropathol. Exp. Neurol., 47: 654-663.
  933. Autilio-Gambetti, L., A. Morandi, M. Tabaton, B. Schaetzle and D. Kovacs et al., 1988. The amyloid precursor protein of Alzheimer disease is expressed as a 130 kDa polypeptide in various cultured cell types. FEBS Lett., 241: 94-98.
    CrossRef  |  Direct Link  |  
  934. Atkinson, C.T., M. Aikawa, G. Perry, T. Fujino, V. Bennett, E.A. Davidson and R.J. Howard, 1988. Ultrastructural localization of erythrocyte cytoskeletal and integral membrane proteins in Plasmodium falciparum-infected erythrocytes. Eur. J. Cell Biol., 45: 192-199.
    PubMed  |  
  935. Perry, G., V. Manetto, M. Onorato, M. Weiss and P. Mulvihill et al., 1987. Alteration of the Neurofilament-Microtubule Network in Alzheimer Disease and other Neurodegenerative Disorders. In: Advances in Behavioral Biology 34: Alterations in the Neuronal Cytoskeleton in Alzheimer Disease, Perry, G. (Ed.)., Plenum Press, New York, pp: 137-149.
  936. Perry, G., V. Manetto and P. Mulvihill, 1987. Ubiquitin in Alzheimer and other Neurodegenerative Diseases. In: Advances in Behavioral Biology34: Alterations in the Neuronal Cytoskeleton in Alzheimer Disease, Perry, G. (Ed.)., Plenum Press, New York, pp: 53-59.
  937. Perry, G., R. Friedman, G. Shaw and V. Chau, 1987. Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains. Proc. Natl. Acad. Sci. USA., 84: 3033-3036.
    Direct Link  |  
  938. Perry, G., R. Friedman, D.H. Kang, V. Manetto, L. Autilio-Gambetti and P. Gambetti, 1987. Antibodies to the neuronal cytoskeleton are elicited by Alzheimer paired helical filament fractions. Brain Res., 420: 233-242.
    CrossRef  |  Direct Link  |  
  939. Perry, G., P. Mulvihill, V. Manetto, L. Autilio-Gambetti and P. Gambetti, 1987. Immunocytochemical properties of Alzheimer straight filaments. J. Neurosci., 7: 3736-3738.
    Direct Link  |  
  940. Perry, G., D. Stewart, R. Friedman, V. Manetto, L. Autilio-Gambetti and P. Gambetti, 1987. Filaments of Pick's bodies contain altered cytoskeletal elements. Am. J. Pathol., 127: 559-568.
    Direct Link  |  
  941. Perry, G., 1987. Immunocytochemical study of the neuronal cytoskeleton in dementia: Alzheimer, Pick and Parkinson diseases. ICN Qual. Line, 2: 6-7.
  942. Matsumoto, Y., G. Perry, L.W. Scheibel and M. Aikawa, 1987. Role of calmodulin in Plasmodium falciparum: Implications for erythrocyte invasion by the merozoite. Eur. J. Cell Biol., 45: 36-43.
    PubMed  |  
  943. Kasper, M., R. Goertchen, P. Stosiek, G. Perry and U. Karsten, 1987. Coexistence of cytokeratin, vimentin and neurofilament protein in human choroid plexus. Virchows Archiv A, 410: 173-177.
    CrossRef  |  Direct Link  |  
  944. Gambetti, P., L. Autilio-Gambetti, V. Manetto and G. Perry, 1987. Composition of Paired Helical Filaments of Alzheimer's Disease as Determined by Specific Probes. In: Banbury Report 27, Molecular Neuropathology of Aging, Davies, P. and C.E. Finch (Eds.). Cold Spring Harbor, New York, pp: 309-320.
  945. Galloway, P.G., G. Perry, K.S. Kosik and P. Gambetti, 1987. Hirano bodies contain tau protein. Brain Res., 403: 337-340.
    CrossRef  |  Direct Link  |  
  946. Galloway, P.G., G. Perry and P. Gambetti, 1987. Hirano body filaments contain actin and actin-associated proteins. J. Neuropathol. Exp. Neurol., 46: 185-199.
  947. Galloway, P.G. and G. Perry, 1987. Microfilament Involvement in Hirano Body Formation. In: Advances in Behavioral Biology 34: Alterations in the Neuronal Cytoskeleton in Alzheimer Disease, Perry, G. (Ed.). Plenum Press, New York, pp: 199-221.
  948. Perry, G., L. Wible and B.R. Brinkley, 1986. Microtubules are not altered in the dystrophic chicken. Exp. Cell Res., 163: 266-272.
    CrossRef  |  Direct Link  |  
  949. Perry, G., D.J. Selkoe, B.R. Block, D. Stewart, L. Autilio-Gambetti and P. Gambetti, 1986. Electron microscopic localization of Alzheimer neurofibrillary tangle components recognized by an antiserum to paired helical filaments. J. Neuropathol. Exp. Neurol., 45: 161-168.
    CrossRef  |  Direct Link  |  
  950. Perry, G. and P. Gambetti, 1986. Conclusions, Discussions and Outlook. The Helix Clock Model of the Neurofilamentous Network. In: Electron Microscopy and Alzheimer's Disease, Metuzals, J. (Ed.)., San Francisco Press, San Francisco, pp: 67-68.
  951. Gambetti, P., G. Perry and L. Autilio-Gambetti, 1986. Paired helical filaments: Do they contain neurofilament epitopes? Neurobiol. Aging, 7: 451-452.
    CrossRef  |  Direct Link  |  
  952. Gambetti, P., G. Perry and L. Autilio-Gambetti, 1986. Alzheimer Paired Helical Filaments Contain Insoluble Cytoskeletal Elements. In: Electron Microscopy and Alzheimer's Disease, Metuzals, J. (Ed.)., San Francisco Press, San Francisco, pp: 50-52.
  953. Perry, G., N. Rizzuto, L. Autilio-Gambetti and P. Gambetti, 1985. Paired helical filaments from Alzheimer disease patients contain cytoskeletal components. Proc. Natl. Acad. Sci. USA., 82: 3916-3920.
    Direct Link  |  
  954. Perry, G. and D. Epel, 1985. Fertilization stimulates lipid peroxidation in the sea urchin egg. Dev. Biol., 107: 58-65.
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  955. Perry, G. and D. Epel, 1985. Characterization of a Ca2+-stimulated lipid peroxidizing system in the sea urchin egg. Dev. Biol., 107: 47-57.
    CrossRef  |  Direct Link  |  
  956. Gambetti, P., G. Perry and L. Autilio-Gambetti, 1985. Alzheimer's Paired Helical Filaments Contain Insoluble Cytoskeletal Elements. In: Proceedings of Electro Microscopy Society of America, Bailey, G.W. (Ed.)., Vol. 43, San Francisco Press, San Francisco, pp: 748-751.
  957. Anderson, D.C., B.J. Hughes, L.J. Wible, G.J. Perry, C.W. Smith and B.R. Brinkley, 1984. Impaired motility of neonatal PMN leukocytes: Relationship to abnormalities of cell orientation and assembly of microtubules in chemotactic gradients. J. Leukoc. Biol., 36: 1-15.
    Direct Link  |  
  958. Pardue, R.L., R.C. Brady, G.W. Perry and J.R. Dedman, 1983. Production of monoclonal antibodies against calmodulin by in vitro immunization of spleen cells. J. Cell Biol., 96: 1149-1154.
    CrossRef  |  Direct Link  |  
  959. Gambetti, P., L. Autilio-Gambetti, G. Perry, G. Shecket and R.C. Crane, 1983. Antibodies to neurofibrillary tangles of Alzheimer's disease raised from human and animal neurofilament fractions. Lab. Invest., 49: 430-435.
    PubMed  |  
  960. Perry, G., B.R. Brinkley and J. Bryan, 1982. Interaction of Calcium-Calmodulin in Microtubule Assembly In Vitro. In: Muscle and Cell Motility, Dowben, R.M. and J.W. Shay (Eds.). Vol. 2., Plenum Press, New York, pp: 73-87.
  961. Epel, D., G. Perry and T. Schmidt, 1982. Intracellular Calcium and Fertilization: Role of the Cation and Regulation of Intracellular Calcium Levels. In: Membranes in Growth and Development, Gerisch, G. and J. Hofman (Eds.). Alan R. Liss, New York, pp: 171-183.
  962. Perry, G. and D. Epel, 1981. Ca2+-stimulated production of H2O2 from naphthoquinone oxidation in Arbacia eggs. Exp. Cell Res., 134: 65-72.
    CrossRef  |  Direct Link  |  
  963. Byrd, W. and G. Perry, 1980. Cytochalasin B blocks sperm incorporation but allows activation of the sea urchin egg. Exp. Cell Res., 126: 333-342.
    CrossRef  |  Direct Link  |  
  964. Epel, D., D. Nishioka and G. Perry, 1978. The role of Ca2+ in triggering development at fertilization. Biol. Cellul., 32: 135-140.