Dr. Antonio Massa
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Dr. Antonio Massa

Associate Professor
University of Salerno, Italy

Highest Degree
Ph.D. in Organic Chemistry from University of Salerno, Italy

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Biography

Dr. Antonio Massa obtained his Ph.D. in Organic Chemistry from University of Salerno, Italy. From October 1996-October 1999: he worked in the company Montefibre S.p.A as Young Researcher. He did applied research on Polyester Polymers. Since January 2004 he is currently working at University of Salerno as Assistant Professor (Researcher). His research interests are in the field of the Development of new Methodologies, Organocatalysis, in Synthesis of Heterocyclic Compounds and in the evaluation of their Biological Activity. In 2008 he was awarded of the Fulbright Research Scholarship. He spent 6 months at the Scripps Research Institute, San Diego - California, as Visiting Investigator in the laboratory of Prof. Carlos F. Barbas III. In 2013 he got the qualification for Associate Professorship. He is currently Associate Professor at the Department of Chemistry and Biology, University of Salerno, Italy. He is in editorial advisory board of Asymmetric Catalysis, De Gruyter Open and Mediterranean Journal of Chemistry. He has been Guest Editor for Current Organic Chemistry Edited by Bentham. Dr. Antonio Massa is leading several research projects and is author of more than 60 publications most of them as corresponding author.

Area of Interest:

Chemistry
100%
Asymmetric Catalysis
62%
Cascade Reactions
90%
Synthesis
75%
Bioactive Compounds
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Scuotto, M., R. Abdelnabi, S. Collarile, C. Schiraldi and L. Delang et al ., 2017. Discovery of novel multi-target indole-based derivatives as potent and selective inhibitors of chikungunya virus replication.ikungunya virus replication. Bioorg. Med. Chem., 25: 327-337.
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  2. Scorzelli, F., A.D. Mola, F.D. Piano, C. Tedesco and L. Palombi, et al ., 2017. A systematic study on the use of different organocatalytic activation modes for asymmetric conjugated addition reactions of isoindolinones. Tetrahedron, 73: 819-828.
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  3. Mola, A.D., A. Massa, V.D. Feo, A. Basile and M. Pascale, et al ., 2017. Effect of citral and citral related compounds on viability of pancreatic and human B-lymphoma cell lines. Med. Chem. Res., 26: 631-639.
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  4. Capaccio, V., A. Capobianco, A. Stanzione, G. Pierri and C. Tedesco et al., 2017. Organocatalytic heterocyclization driven by dynamic kinetic resolution: Enantioselective access to multi-heteroatomic cyclic structures mediated by cinchona alkaloid-based catalysts. Adv. Synth. Catal., 359: 2874-2880.
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  5. Peduto, A., V. Krauth, S. Collarile, F. Dehm and M. Ambruosi, et al ., 2016. Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition R. Eur. J. Med. Chem., 108: 466-475.
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  6. Mola, A.D., T. Caruso, P.D. Caprariis and A. Massa, 2016. Reaction of benzal bromides in water/dioxane system for easy access to benzaldehydes and 2-formylbenzonitriles (2-cyanobenzaldehydes). Arch. Org. Chem., 4: 10-21.
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  7. Mola, A.D., F. Scorzelli, G. Monaco, L. Palombi and A. Massa, 2016. Highly diastereo- and enantioselective organocatalytic synthesis of new heterocyclic hybrids isoindolinone-imidate and isoindolinone-phthalide R. Soc. Chem., 6: 60780-60786.
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  8. Mola, A.D., E. Gatta, C. Petronzi, A. Cupello and P.D. Caprariis et al ., 2016. Synthesis and pharmacological evaluation of functionalized isoindolinones on GABA-activated chloride currents in rat cerebellum granule cells in culture. Bioorg. Med. Chem. Lett., 26: 5284-5289.
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  9. Capobianco, A., A.D. Mola, V. Intintoli, A. Massa and V. Capaccio, et al ., 2016. Asymmetric tandem hemiaminal-heterocyclization-aza-Mannich reaction of 2-formylbenzonitriles and amines using chiral phase transfer catalysis: an experimental and theoretical study R. Soc. Chem. Adv., 6: 31861-31870.
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  10. Tiso, S., and A. Massa, 2015. Chiral phase transfer catalysts enable the synthesis of diverse chiral N-heterocycles through a combination of asymmetric cascade reactions. J. Heterocycl. Chem. Press, .
  11. Tiffner, M., J. Novacek, A. Busillo, K. Gratzer and A. Massa et al ., 2015. Design of chiral urea-quaternary ammonium salt hybrid catalysts for asymmetric reactions of glycine Schiff bases. R. Soc. Chem. Adv., 5: 78941-78949.
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  12. Scorzelli, F., A.D. Mola, L. Palombi and A. Massa, 2015. Isoindolinones as Michael Donors under Phase Transfer Catalysis: Enantioselective Synthesis of Phthalimidines Containing a Tetrasubstituted Carbon Stereocenter. Mol., 20: 8484-8498.
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  13. Scorzelli, F., A. Di Mola, L. Palombi, R. Filosa and A. Massa, 2015. 3-Carboxylate-Substituted Isoindolinones in K2CO3-Catalyzed Michael Reactions. Synth. Commun., 45: 1-7.
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  14. Scorzelli, F., A. Di Mola, L. Palombi, R. Filosa and A. Massa, 2015. 3-Carboxylate-Substituted Isoindolinones in K2CO3-Catalyzed Michael Reactions. Synth. Commun., 10.1080/00397911.2015.1033063.
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  15. Scorzelli, F., A. Di Mola, G. Croce, L. Palombi and A. Massa, 2015. Organocatalytic asymmetric synthesis of highly functionalized pyrrolizidines via cascade Michael/hemi-aminalization reactions of isoindolinones. Tetrahedron Lett., 56: 2787-2790.
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  16. Mola, A.D., M. Tiffner, F. Scorzelli, L. Palombi and R. Filosa et al ., 2015. Bifunctional phase-transfer catalysis in the asymmetric synthesis of biologically active isoindolinones. Beilstein J. Org. Chem., 11: 2591-2599.
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  17. Di Mola, A., L. Palombi and A. Massa, 2015. An Overview on asymmetric synthesis of 3-substituted isoindolinones. Targets Heterocycl. Syst. Press, .
  18. Perillo, M., A. Di Mola, R. Filosa, L. Palombi and A. Massa, 2014. Cascade reactions of glycine Schiff bases and chiral phase transfer catalysts in the synthesis of α-amino acids 3-substituted phthalides or isoindolinones. RSC Adv., 4: 4239-4246.
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  19. Palombi, L., A. Di Mola, C. Vignes and A. Massa, 2014. Combined electrochemical/chemical methods for the synthesis and the molecular diversifying of isoindolinone-based heterocyclic scaffolds. Mol. Diversity, 18: 323-333.
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  20. Di Mola, A., L. Palombi and A. Massa, 2014. An Overview on Asymmetric Synthesis of 3-Substituted Isoindolinones. In: Targets in Heterocyclic Systems, Volume 18: Chemistry and Properties, Attanasi, O.A., R. Noto and D. Spinelli (Eds.). Chapter 5, Italian Society of Chemistry, Italy, pp: 113-140.
  21. Di Matteo, L., O. Christodoulakis, R. Filosa, P. De Caprariis, A. Di Mola, E. Vasca and A. Massa, 2014. New chelating agents for Cu(II), Fe(III), Al(III) and Zn(II) based on β-diketonate-3-substituted phthalide (isobenzofuranone) and isoindolinone. J. Coord. Chem., 67: 2217-2228.
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  22. Tiso, S., L. Palombi, C. Vignes, A. Di Mola and A. Massa, 2013. Organocatalysts and sequential asymmetric cascade reactions in the synthesis of functionalized isoindolinones and benzoindolizidinones. RSC Adv., 3: 19380-19387.
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  23. Petronzi, C., M. Festa, A. Peduto, M. Castellano, J.Marinello, A. Massa and R. Filosa, 2013. Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: Design, synthesis, and cytotoxic evaluation. J. Exp. Clin. Cancer Res., 10.1186/1756-9966-32-24.
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  24. Massa, A., P. Rizzo, G. Monaco and R. Zanasi, 2013. Absolute configuration assignment made easier by the VCD of coupled oscillating carbonyls: the case of (−)-propanedioic acids, 2-(2,3)-dihydro-3-oxo-1H-isoindol-1-yl)-1,3-dimethyl ester. Tetrahedron Lett., 54: 6242-6246.
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  25. Filosa, R., A. Peduto, P. Aparoy, A.M. Schaible, S. Luderer, V. Krauth and O. Werz, 2013. Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase. Eur. J. Med. Chem., 67: 269-279.
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  26. Petronzi, C., S. Collarile, G. Croce, R. Filosa, P. De Caprariis, A. Peduto and A. Massa, 2012. Synthesis and Reactivity of the 3-Substituted Isoindolinone Framework to Assemble Highly Functionalized Related Structures. Eur. J. Org. Chem., 2012: 5357-5365.
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  27. More, V., R. Rohlmann, O.G. Mancheno, C. Petronzi, L. Palombi, A. De Rosa and A. Massa, 2012. The first organocatalytic asymmetric synthesis of 3-substituted isoindolinones. RSC Adv., 2: 3592-3595.
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  28. Monaco, G., C. Vignes, F. De Piano, A. Bosco and A. Massa, 2012. Chiral sulfoxides in the enantioselective allylation of aldehydes with allyltrichlorosilane: a kinetic study. Org. Biomol. Chem., 10: 9650-9659.
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  29. Massa, A., 2012. New reactions exploring the chemical spaces of the aldol addition of active methylene compounds. Synlett, 2012: 524-530.
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  30. Massa, A., 2012. Editorial [Hot Topic: Recent Advances in the Chemistry of Active Methylene Compounds]. Curr. Org. Chem., 16: 2159-2159.
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  31. Di Mola, A., L. Palombi and A. Massa, 2012. Active methylene compounds in the synthesis of 3-substituted isobenzofuranones, isoindolinones and related compounds. Curr. Org. Chem., 16: 2302-2320.
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  32. Di Mola, A., G. Croce, V. More, P. De Caprariis, R. Filosa and A. Massa, 2012. Active methylene compounds in a very effective approach to 3-substituted isobenzofuranones through tandem aldol/lactonization reactions. Tetrahedron, 68: 6146-6151.
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  33. Di Mola, A. and A. Massa, 2012. The Aldol Reactions of Active Methylene Compounds. Curr. Org. Chem., 16: 2290-2301.
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  34. Antico, P., V. Capaccio, A. Di Mola, A. Massa and L. Palombi, 2012. Electrochemically Initiated Tandem and Sequential Conjugate Addition Processes: One-Pot Synthesis of Diverse Functionalized Isoindolinones. Adv. Synth. Catal., 354: 1717-1724.
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  35. Petronzi, C., R. Filosa, A. Peduto, M.C.Monti, L. Margarucci, A. Massa and P. de Caprariis, 2011. Structure-based design, synthesis and preliminary anti-inflammatory activity of bolinaquinone analogues. Eur. J. med. Chem., 46: 488-496.
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  36. Peduto, A., B. Pagano, C. Petronzi, A. Massa, V. Esposito, A. Virgilio and R. Filosa, 2011. Design, synthesis, biophysical and biological studies of trisubstituted naphthalimides as G-quadruplex ligands. Bioorg. Med. Chem., 19: 6419-6429.
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  37. Peduto, A., A. Massa, P. de Caprariis, P. La Colla, R. Loddo, G. Maga, S. Altamura and R. Filosa, 2011. 2,3-dihydro-1,2-diphenyl-substituted 4H-pyridinone derivatives as new anti flaviviridae inhibitors. Chem. Biol. Drug Des., 77: 441-449.
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  38. More, V., A. Di Mola, G. Croce, C. Tedesco, C. Petronzi, et al. , 2011. A one-pot multicomponent methodology for the aldol addition β-ketoesters: scope and applications. Org. Biomol. Chem., .
  39. Massa, A., V. Bugatti, A. Scettri and S. Contessa, 2011. Thermo-Oxidation Stability of Poly(Butylene Terephthalate) and Catalyst Composition. In: Polymer Aging, Stabilizers and Amphiphilic Block Copolymers, Segewicz, L. and M. Petrowsky (Eds.). Chapter 10, Nova Science Publisher, USA., ISBN: 978-1-60692-928-5.
  40. Massa, A., 2011. The aldol addition of readily enolizable 1, 3-dicarbonyl compounds to 2-cyanobenzaldehyde in the synthesis of novel 3-substituted isoindolinones. Synth., .
  41. Massa, A., L. Capozzolo and A. Scettri, 2010. Sulfoxides in the allylation of aldehydes in the presence of silicon tetrachloride and allyltributylstannane. Open Chem., 8: 1210-1215.
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  42. Massa, A., A. Roscigno, P. De Caprariis, R. Filosa and A. Di Mola, 2010. Trimethylchlorosilane and Silicon Tetrachloride in Two Novel Methodologies for the Efficient and Mild Aldol Addition of β-Keto Esters and Malonates to Aldehydes. Adv. Synth. Catal., 352: 3348-3354.
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  43. De Sio, V., A. Massa and A. Scettri, 2010. Chiral sulfoxides as activators of allyl trichlorosilanes in the stereoselective allylation of aldehydes. Org. biomol. Chem., 8: 3055-3059.
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  44. Villano, R., M.R. Acocella, A. Massa, L. Palombi and A. Scettri, 2009. Solvent-free asymmetric vinylogous aldol reaction of Chan's diene with aromatic aldehydes catalyzed by hydrogen bonding. Tetrahedron, 65: 5571-5576.
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  45. Massa, A., V. de Sio, R. Villano, M. Rosaria Acocella, L. Palombi, G. Sellitto and A. Scettri, 2009. A New Approach to Di-and Tetrasubstituted 2, 3-Dihydropyridin-4 (1H)-ones through Aza-Diels-Alder Reaction Promoted by Silicon Tetrachloride. Synth., 4: 643-649.
  46. Massa, A., N. Utsumi and C.F. Barbas III, 2009. N-Tosylimidates in highly enantioselective organocatalytic Michael reactions. Tetrahed. Lett., 50: 145-147.
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  47. Massa, A., M.R. Acocella, V. De Sio, R. Villano and A. Scettri, 2009. A catalytic asymmetric allylation of aldehydes with allyl trichlorosilane activated by a chiral tetradentate bis-sulfoxide. Tetrahedron: Asymmetry, 20: 202-204.
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  48. Massa, A., A. Scettri, R. Filosa and L. Capozzolo, 2009. Synthesis of β-hydroxymalonates: the direct aldol addition of malonates to aldehydes in the presence of SiCl4 and i-Pr2EtN. Tetrahedron Lett., 50: 7318-7321.
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  49. Scettri, A., A. Massa, L. Palombi, R. Villanoa and M.R. Acocella, 2008. Organocatalytic asymmetric aza-Michael addition of aniline to chalcones under solvent-free conditions. Tetrahedron: Asymmetry, 19: 2149-2152.
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  50. Mazzeo, M., M. Lamberti, A. Massa, A. Scettri, C. Pellecchia and J.C. Peters, 2008. Phosphido pincer complexes of palladium as new efficient catalysts for allylation of aldehydes. Organometallics, 27: 5741-5743.
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  51. Massa, A., V. Bugatti, A. Scettri, S. Contessa, 2008. The Effect Of Additives And Complexing Agents On The Synthesis And Thermo-Oxidation Stability Of Poly(Butylene Terephthalate). Macromol. Indian J., 4: 45-50.
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  52. Villano, R., M.R. Acocella, A. Massa, L. Palombi and A. Scettri, 2007. Enantioselective vinylogous aldol reaction of Chan's diene catalyzed by hydrogen-bonding. Tetrahedron Lett., 48: 891-895.
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  53. Villano, R., M.R. Acocella, A. Massa, L. Palombi and A. Scettri, 2007. A convenient approach to δ-amino-β-ketoesters by vinylogous Mannich reaction of masked acetoacetates. Tetrahedron, 63: 12317-12323.
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  54. Massa, A., A. Scettri, S. Contessa, V. Bugatti, S. Concilio and P. Iannelli, 2007. New catalyst for the synthesis of poly(butylene terephthalate) with high thermo-oxidative stability. J. Appl. Polym. Sci., 104: 3071-3076.
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  55. Villano, R., M.R. Acocella, A. Massa, L. Palombi and A. Scettri, 2006. A new procedure for the enantioselective vinylogous aldol reaction of Chan's diene. Tetrahedron: Asymmetry, 17: 3332-3334.
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  56. Scettri, A., M.R. Acocella, L. Palombi, C. Scalera, R. Villano and A. Massa, 2006. Diastereo- and Enantioselective Synthesis of trans-2,3-Disubstituted 2,3-Dihydropyran-4-one Derivatives. Adv. Synth. Catal., 348: 2229-2236.
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  57. Palombi, L., M.R. Acocella, N. Celenta, A. Massa, R. Villano and A. Scettri, 2006. Highly enantioselective vinylogous addition of 2-trimethylsilyloxyfuran to aldehydes promoted by the SiCl4/chiral Lewis base system. Tetrahedron: Asymmetry, 17: 3300-3303.
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  58. Massa, A., E.M. De Lorenzo and A. Scettri, 2006. Polymeric Ti(IV) glycolate: A heterogeneous catalyst for solvent-free sulfoxidation by t-butyl hydroperoxide. J. Mol. Catal. A: Chem., 250: 27-29.
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  59. Massa, A., V. Mazza and A. Scettri, 2005. A re-investigation of Modena's protocol for the asymmetric oxidation of prochiral sulfides. Tetrahedron: Asymmetry, 16: 2271-2275.
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  60. Acocella, M.R., M. De Rosa, A. Massa, L. Palombi, R. Villano and A. Scettri, 2005. Silicon tetrachloride in organic synthesis: new applications for the vinylogous aldol reaction. Tetrahedron, 61: 4091-4097.
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  61. Acocella, M.R., A. Massa, L. Palombi, R. Villano and A. Scettri, 2005. Solvent-free Mukaiyama aldol reaction of O-silyl dienolates catalyzed by benzoic acid. Tetrahedron Lett., 46: 6141-6144.
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  62. Massa, A., M.R. Acocella, M. De Rosa, A. Soriente, R. Villano and A. Scettri, 2003. Mo(CO)6-catalyzed oxidation of furan derivatives to E- and Z-enediones by cumyl hydroperoxide. Tetrahedron Lett., 44: 835-837.
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  63. Massa, A., A.V. Malkov, P. Kocovsky and A. Scettri, 2003. Asymmetric allylation of aldehydes with allyltrichlorosilane promoted by chiral sulfoxides. Tetrahedron Lett., 44: 7179-7181.
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  64. Malkov, A.V., M. Bell, M. Orsini, D. Pernazza, A. Massa, P. Herrmann and P. Koc ovsky, 2003. New Lewis-basic N-oxides as chiral organocatalysts in asymmetric allylation of aldehydes. J. org. chem., 68: 9659-9668.
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  65. Malkov, A.V., D. Pernazza, M. Bell, M. Bella, A. Massa, F. Teply and P. Kocovsky, 2003. Synthesis of new chiral 2, 2'-bipyridine ligands and their application in copper-catalyzed asymmetric allylic oxidation and cyclopropanation. J. org. chem., 68: 4727-4742.
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  66. Lattanzi, A., L.R. Orelli, P. Barone, A. Massa, P. Iannece and A. Scettri, 2003. Convenient procedure of Horner-Wadsworth-Emmons olefination for the synthesis of simple and functionalized α,β-unsaturated nitriles. Tetrahedron Lett., 44: 1333-1337.
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  67. Lattanzi, A., A. Senatore, A. Massa and A. Scettri, 2003. Novel highly regioselective VO(acac)2/TBHP mediated oxidation of o-alkenyl phenols to o-hydroxybenzyl ketones. J. Org. Chem., 68: 3691-3694.
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  68. Massa, A., F.R. Siniscalchi, V. Bugatti, A. Lattanzi and A. Scettri, 2002. New procedures for the enantioselective oxidation of sulfides under stoichiometric and catalytic conditions. Tetrahedron: Asymmetry, 13: 1277-1283.
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  69. Acierno, D., E. Amendola, S. Concilio, P. Iannelli, A. Massa and P. Scarfato, 2002. Matrices for mono-material composites (MMC). The case of poly(ethylene terephthalate). Macromol. Symp., 180: 61-72.
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  70. Massa, A., L. Palombi and A. Scettri, 2001. A convenient approach to renewable hydroperoxides. Tetrahedron Lett., 42: 4577-4579.
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  71. Massa, A., A. Lattanzi, F.R. Siniscalchi and A. Scettri, 2001. Catalytic enantioselective oxidation of sulfides to sulfoxides with a renewable hydroperoxide. Tetrahedron: Asymmetry, 12: 2775-2777.
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  72. Massa, A., A. D'Ambrosi, A. Proto and A. Scettri, 2001. Critical importance of molecular sieves in titanium(IV)-calix[4]arene catalyzed epoxidation of allylic alcohols. Tetrahedron Lett., 42: 1995-1998.
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  73. Massa, A. and A. Scettri, 2000. Epoxidation of Allylic Alcohols by Polymeric Ti(IV) Glycolates. Synlett, 2000: 1348-1350.
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